P
Peter K. Jackson
Researcher at Stanford University
Publications - 219
Citations - 22223
Peter K. Jackson is an academic researcher from Stanford University. The author has contributed to research in topics: Cilium & Ubiquitin ligase. The author has an hindex of 73, co-authored 195 publications receiving 19927 citations. Previous affiliations of Peter K. Jackson include University of Vermont Medical Center & Massachusetts Institute of Technology.
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Journal ArticleDOI
Neonatal lethality and lymphopenia in mice with a homozygous disruption of the c-abl proto-oncogene
Victor L. J. Tybulewicz,Camila E. Crawford,Peter K. Jackson,Roderick T. Bronson,Richard C. Mulligan +4 more
TL;DR: The c-abl proto-oncogene, which encodes a cytoplasmic protein-tyrosine kinase, is expressed throughout murine gestation and ubiquitously in adult mouse tissues, however, its levels are highest in thymus, spleen, and testes.
Journal ArticleDOI
A Core Complex of BBS Proteins Cooperates with the GTPase Rab8 to Promote Ciliary Membrane Biogenesis
Maxence V. Nachury,Alexander V. Loktev,Qihong Zhang,Christopher J. Westlake,Johan Peränen,Andreas Merdes,Diane C. Slusarski,Richard H. Scheller,J. Fernando Bazan,Val C. Sheffield,Peter K. Jackson +10 more
TL;DR: The data reveal that BBS may be caused by defects in vesicular transport to the cilium, and a complex composed of seven highly conserved BBS proteins is identified, the BBSome, which localizes to nonmembranous centriolar satellites in the cytoplasm but also to the membrane of the cILium.
Journal ArticleDOI
Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7
Ingrid E. Wertz,Saritha Kusam,Cynthia Lam,Toru Okamoto,Wendy Sandoval,Daniel Anderson,Elizabeth Helgason,James A. Ernst,Mike Eby,Jinfeng Liu,Lisa D. Belmont,Joshua S. Kaminker,Karen O'Rourke,Kanan Pujara,Pawan Bir Kohli,Adam R. Johnson,Mark L. Chiu,Jennie R. Lill,Peter K. Jackson,Wayne J. Fairbrother,Somasekar Seshagiri,Mary J. C. Ludlam,Kevin G. Leong,Erin C. Dueber,Heather Maecker,David C.S. Huang,David C.S. Huang,Vishva M. Dixit +27 more
TL;DR: Highlights suggest that profiling the FBW7 and MCL1 status of tumours, in terms of protein levels, messenger RNA levels and genetic status, could be useful to predict the response of patients to antitubulin chemotherapeutics.
Journal ArticleDOI
The lore of the RINGs: substrate recognition and catalysis by ubiquitin ligases.
Peter K. Jackson,Adam G. Eldridge,Ellen Freed,Laura Furstenthal,Jerry Y. Hsu,Brett K. Kaiser,Julie D.R. Reimann +6 more
TL;DR: The separable substrate-recognition domains of E3 enzymes provides a flexible means of linking a conserved ubiquitylation function to potentially thousands of ubiquitylated substrates in eukaryotic cells.