M
Magdalena Malgowska
Researcher at Polish Academy of Sciences
Publications - 6
Citations - 319
Magdalena Malgowska is an academic researcher from Polish Academy of Sciences. The author has contributed to research in topics: RNA & G-quadruplex. The author has an hindex of 5, co-authored 6 publications receiving 237 citations.
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Journal ArticleDOI
The contribution of pseudouridine to stabilities and structure of RNAs
Elzbieta Kierzek,Magdalena Malgowska,Jolanta Lisowiec,Douglas H. Turner,Zofia Gdaniec,Ryszard Kierzek +5 more
TL;DR: Structural and thermodynamic data are reported revealing that pseudouridine (Ψ) can stabilize RNA duplexes when replacing U and forming Ψ-A, Ω-G, ά-U and Ψ -C pairs, and these structural and thermodynamics properties may contribute to the biological functions of Ψ.
Journal ArticleDOI
Distinctive structural motifs of RNA G-quadruplexes composed of AGG, CGG and UGG trinucleotide repeats
Magdalena Malgowska,Dorota Gudanis,Ryszard Kierzek,Eliza Wyszko,Valérie Gabelica,Valérie Gabelica,Valérie Gabelica,Zofia Gdaniec +7 more
TL;DR: This NMR study highlights that although potassium ions are prevalent in cells, the structures observed in the HeLa cell extract are not always the same as those prevailing in biophysical studies in the presence of K+ ions.
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Overview of the RNA G-quadruplex structures.
TL;DR: This review focuses on structural properties of the RNA G-quadruplexes, based on high-resolution structures available in the RCSB PDB data base and on structural models and points out the current challenges in this field of research.
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Computational and NMR studies of RNA duplexes with an internal pseudouridine-adenosine base pair.
Indrajit Deb,Łukasz Popenda,Joanna Sarzynska,Magdalena Malgowska,Ansuman Lahiri,Zofia Gdaniec,Ryszard Kierzek +6 more
TL;DR: The results showed a subtle impact from Ψ modification on the structure and dynamics of the RNA duplexes studied, and quantum chemical calculations showed that the replacement of U with Ψ affected the intrinsic stacking energies at the base pair steps depending on the sequence context.
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How to study G-quadruplex structures
TL;DR: A short review of experimental methods commonly used to determine G-quadruplex topologies and their roles in guanine-rich DNA and RNA molecules.