Mahendra Pratap Singh

TL;DR: Light is shed on cypermethrin-induced changes in the central nervous system, including its contribution in the onset of specific features, which are associated with the nigrostriatal dopaminergic neurodegeneration.

TL;DR: In this paper, the effects of silymarin, an antioxidant of plant origin, and melatonin, an indoleamine produced in all species, in MB-and PQ-induced mouse model of Parkinson's disease (PD) were investigated.

TL;DR: Investigation of the effects of cypermethrin on biochemical, histopathological, and motor behavioral indices of the nigrostriatal dopaminergic system in adult rats treated with or without cypermEthrin demonstrates that exposure to cypermETHrin during adulthood induces dopamine neurodegeneration in rats and postnatal exposure enhances the susceptibility of animals to dopaminerential neurodegenersation if rechallenged during adulthood.

TL;DR: Results obtained from the present investigation suggest the involvement of CYP2E1 and GSTA4-4 in the augmentation of the lipid peroxidation thereby enhancing neurodegeneration.

TL;DR: It is demonstrated that nitric oxide contributes to an increase of MB- and PQ-induced lipid peroxidation in mouse striatum and tyrosine kinase, p38 MAPK and NF-kB regulate iNOS expression.