G
Garima Srivastava
Researcher at Council of Scientific and Industrial Research
Publications - 16
Citations - 583
Garima Srivastava is an academic researcher from Council of Scientific and Industrial Research. The author has contributed to research in topics: Paraquat & Maneb. The author has an hindex of 10, co-authored 15 publications receiving 516 citations. Previous affiliations of Garima Srivastava include Indian Institute of Toxicology Research.
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Journal ArticleDOI
Melatonin or silymarin reduces maneb- and paraquat-induced Parkinson’s disease phenotype in the mouse
Naveen Kumar Singhal,Garima Srivastava,Devendra Kumar Patel,Swatantra Kumar Jain,Mahendra Pratap Singh +4 more
TL;DR: In this paper, the effects of silymarin, an antioxidant of plant origin, and melatonin, an indoleamine produced in all species, in MB-and PQ-induced mouse model of Parkinson's disease (PD) were investigated.
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Melatonin as a Neuroprotective Agent in the Rodent Models of Parkinson's Disease: Is it All Set to Irrefutable Clinical Translation?
Naveen Kumar Singhal,Garima Srivastava,Sonal Agrawal,Swatantra Kumar Jain,Mahendra Pratap Singh +4 more
TL;DR: An update on the usage and applications of melatonin in PD models along with incongruous observations is presented and the impending implications in the clinics, success, limitations, and future prospective have been discussed.
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Resveratrol potentiates cytochrome P450 2 d22-mediated neuroprotection in maneb- and paraquat-induced parkinsonism in the mouse
Garima Srivastava,Anubhuti Dixit,Sharawan Yadav,Devendra Kumar Patel,Om Prakash,Mahendra Pratap Singh +5 more
TL;DR: The results obtained in the study demonstrate that Cyp2d22 offers neuroprotection in maneb- and paraquat-induced dopaminergic neurodegeneration and resveratrol enhances its neuroprotective credentials by influencing Cyp1d22 expression and paraqat accumulation.
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Minocycline, levodopa and MnTMPyP induced changes in the mitochondrial proteome profile of MPTP and maneb and paraquat mice models of Parkinson's disease.
Anubhuti Dixit,Garima Srivastava,Divya Verma,Manisha Mishra,Pradhyumna Kumar Singh,Om Prakash,Mahendra Pratap Singh +6 more
TL;DR: It is demonstrated that MPTP and combined maneb and paraquat induce mitochondrial dysfunction and microglial activation and alter the expression of a bunch of mitochondrial proteins leading to the nigrostriatal dopaminergic neurodegeneration and minocycline, levodopa or MnTMPyP variably offset scores of such changes.
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Involvement of NADPH oxidase and glutathione in zinc-induced dopaminergic neurodegeneration in rats: Similarity with paraquat neurotoxicity
Ashutosh Kumar,Brajesh Kumar Singh,Israr Ahmad,Smriti Shukla,Devendra Kumar Patel,Garima Srivastava,Vinod Kumar,Haushila Prasad Pandey,Chetna Singh +8 more
TL;DR: It is suggested that Zn induces oxidative stress via the activation of NADPH oxidase and depletion of GSH, which in turn activate the apoptotic machinery leading to dopaminergic neurodegeneration similar to PQ.