Mahir Kotuk

TL;DR: Treatment with free radical scavenger erdosteine attenuated increases in plasma creatinine and BUN, and tissue MDA and NO levels, and provided a histologically-proven protection against cisplatin-induced acute renal failure.

TL;DR: The data suggest that Ginkgo biloba has a potent antioxidant activity in the model of bleomycin-induced lung fibrosis in rats, and therefore has a powerful antifibrotic activity against bleomyin-induced Lung fibrosis model in rats.

TL;DR: It is revealed that melatonin may prevent the development of bleomycin‐induced lung fibrosis via the repression of protein and lipid peroxidation via the inhibition of catalase and glutathione peroxidase.

TL;DR: Data presented here indicate that aminoguanidine and erdosteine prevented bleomycin-induced lung fibrosis and that nitric oxide mediated tyrosine nitration of proteins plays a significant role in the pathogenesis of bleomycil fibrosis, and suggest that antifibrotic affect of antioxidants may be due to their inhibitory effect on nitrous oxide generation in this model.

TL;DR: Data presented here indicate that erdosteine and NAC similarly prevented bleomycin-induced lung fibrosis and their antioxidant effects were also similar in this experiment.