Showing papers in "Pharmacological Research in 2006"

TL;DR: A better understanding of the relative contribution of the two types of receptors and evidence for the in vivo involvement of alpha2-adrenoceptors in the physiological control of subcutaneous adipose tissue lipolysis are provided.

TL;DR: It is demonstrated that a scope of key endogenous antioxidants and phase 2 enzymes in cultured ASMCs can be upregulated by resveratrol at low micromolar concentrations, and that such chemically-elevated cellular defenses rendered cells increased resistance to oxidative and electrophilic stress.

TL;DR: Findings indicate that ISL has the protective potential against cerebral ischemia injury and its protective effects may be due to the amelioration of cerebral energy metabolism and its antioxidant property.

TL;DR: The pattern of ADRs reported in a tertiary care teaching hospital in South India is comparable with the results of studies conducted in hospital set up elsewhere, and opportunities for interventions especially for the preventable ADRs to ensure safer drug use are revealed.

TL;DR: A channel mutation responsible for one type of a relatively common rhythm disturbance, sinus bradycardia, has been recently identified, highlighting the clinical relevance of funny channels in the pacemaker function.

TL;DR: An overview of the factors involved in different steps of the angiogenic process is given, divided into factors affecting endothelial proliferation and migration and factors affecting blood coagulation, fibrinolysis and the degradation of basement membranes and the extra-cellular matrix.

TL;DR: The cytotoxic effects of isorhamnetin showed dose- and time-dependency against human hepatocellular carcinoma cells (BEL-7402) with the appearance of a hypodiploid peak (sub-G(0)/G(1) peak), probably due to the presence of cells in apoptosis and apoptotic bodies with DNA content less than 2n.

TL;DR: Data obtained from this study indicate that ALC could increase the endogenous antioxidant defense mechanism in rat and there by protect the animals from radiation-induced organs toxicity.

TL;DR: Results suggest that a selective IKACh blocker is effective in canine AF models without affecting ventricular repolarisation, and might be useful for the treatment of patients with AF.

TL;DR: The results indicated that the degraded lambda-carrageenan could add the antitumor activities of 5- Fu and improve the immunocompetence damaged by 5-Fu.

TL;DR: The present results suggest that the vasorelaxant effect of harmaline but not harmine is related to its action on the prostacyclin pathway and on the endothelial cells to release NO.

TL;DR: Data from this study suggest for the first time that carnitine deficiency and oxidative stress are risk factors and should be viewed as mechanisms during development of CDDP-related cardiomyopathy and that Carnitine supplementation, using PLC, prevents the progression ofCDDP-induced cardiotoxicity.

TL;DR: It seems likely that montelukast protects kidney tissue by inhibiting neutrophil infiltration, balancing oxidant-antioxidant status, and regulating the generation of inflammatory mediators.

TL;DR: The studies indicate that GTS, ginsenosides Rg3 and Rb1 may play a neuroprotective role in the immobilization-stressed brain.

TL;DR: Investigation of the effect of vanadyl sulfate on blood glucose, serum and tissue lipid profiles and on stomach and spleen tissues in STZ-induced diabetic rats reveals that diabetes mellitus increased oxidative damage in stomach andSpleen tissues and vanadol sulfate has an ameliorating effect on the oxidative stress via its antioxidant property.

TL;DR: The results suggest that the inhibition of cholesterol absorption caused by silymarin and its polyphenolic fraction could be a mechanism contributing to the positive changes in plasma cholesterol lipoprotein profile and in lipid content in liver.

TL;DR: Ginkgo biloba may be effective in the treatment of UC through its scavenging effect on oxygen-derived free radicals, and significantly decreased colonic MPO activity, TNF-alpha, and IL-1beta levels and increased GSH concentration.

TL;DR: HRT, decreasing Th1 cytokines (TNFalpha, IL-1beta) probably improve the aberation of Th1/Th2 balance that is implicated in various pathological conditions and may help to reverse the increased urinary Hyp and Ca excretion to the premenopausal level.

TL;DR: A working model is provided explaining how cellular inflammatory responses arise to cope with obesity-induced metabolic stresses and how these inflammatory responses underlie insulin resistance.

TL;DR: It is suggested that matrine improves TNBS-induced colitis in mice and the therapeutic mechanism might be related to the reduction of up-regulated colonic TNF-alpha production caused by TNBS.

TL;DR: Piceatannol is identified as a novel phytochemical inducer of HO-1 expression and the mechanisms involved in this process are identified.

TL;DR: It is suggested that the physiological role of PPARdelta may be an indicator for switching from glucose metabolism to fatty acid metabolism, and to receive new benefits of PPardelta agonists against metabolic syndrome by increasing fatty acid consumption in skeletal muscle and adipose tissue.

TL;DR: It is concluded that CO released from CORM-A1 causes an increase in RBF and a decrease in vascular resistance through activation of sGC and opening of Kca channels in the kidney of the mouse.

TL;DR: The data indicate that piceatannol exhibits anti-inflammatory properties by suppressing the transcription of proinflammatory cytokine genes through the NF-κB signaling pathway, and may be useful for attenuating inflammatory diseases and LPS-stimulated microglial activation.

TL;DR: Large ongoing clinical trials aim to assess the therapeutic value of ivabradine to improve the prognosis of patients with stable coronary disease and left ventricular systolic dysfunction by reducing mortality and the occurrence of major cardiovascular events.

TL;DR: Crocetin prevents AGEs-induced BEC apoptosis through ROS inhibition and [Ca2+]i stabilization and suggest that crocetin may exert a beneficial effect in preventing diabetes-associated vascular complications.

TL;DR: Argan oil reduces cardiovascular risk and may be used as anti-atherogenic oil and its consumption could protect against atherosclerosis and cancer via a variety of biological mechanisms.

TL;DR: The data suggest that Ginkgo biloba has a potent antioxidant activity in the model of bleomycin-induced lung fibrosis in rats, and therefore has a powerful antifibrotic activity against bleomyin-induced Lung fibrosis model in rats.

TL;DR: Liposomes incorporating sclareol at a drug to lipid molar ratio of 0:43, suggesting an incorporation efficiency of almost 80%, showed reduced growth rate of human colon cancer tumors (HCT116) developed in SCID mice, without any significant side effects.

TL;DR: It is concluded that low concentrations of ASP metabolites had no effect on the membrane enzyme activity, whereas high or toxic concentrations partially or remarkably decreased the membrane AChE activity, respectively.