抗原变异可使得多种致病微生物易于逃避宿主免疫应答。表达在感染红细胞表面的恶性疟原虫红细胞表面蛋白1（PfPMP1）与感染红细胞、内皮细胞、树突状细胞以及胎盘的单个或多个受体作用，在黏附及免疫逃避中起关键的作用。每个单倍体基因组var基因家族编码约60种成员，通过启动转录不同的var基因变异体为抗原变异提供了分子基础。

疟原虫var基因转换速率变化导致抗原变异[英]／Paul H, Robert P, Christodoulou Z, et al//Proc Natl Acad Sci U S A

Topological insulators are new states of quantum matter which cannot be adiabatically connected to conventional insulators and semiconductors. They are characterized by a full insulating gap in the bulk and gapless edge or surface states which are protected by time-reversal symmetry. These topological materials have been theoretically predicted and experimentally observed in a variety of systems, including HgTe quantum wells, BiSb alloys, and Bi2Te3 and Bi2Se3 crystals. Theoretical models, materials properties, and experimental results on two-dimensional and three-dimensional topological insulators are reviewed, and both the topological band theory and the topological field theory are discussed. Topological superconductors have a full pairing gap in the bulk and gapless surface states consisting of Majorana fermions. The theory of topological superconductors is reviewed, in close analogy to the theory of topological insulators.

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Topological insulators and superconductors

We show that the quantum spin Hall (QSH) effect, a state of matter with topological properties distinct from those of conventional insulators, can be realized in mercury telluride–cadmium telluride semiconductor quantum wells. When the thickness of the quantum well is varied, the electronic state changes from a normal to an “inverted” type at a critical thickness d c . We show that this transition is a topological quantum phase transition between a conventional insulating phase and a phase exhibiting the QSH effect with a single pair of helical edge states. We also discuss methods for experimental detection of the QSH effect.

Quantum Spin Hall Effect and Topological Phase Transition in HgTe Quantum Wells

Anyons in an exactly solved model and beyond

Weyl and Dirac semimetals are three-dimensional phases of matter with gapless electronic excitations that are protected by topology and symmetry. As three-dimensional analogs of graphene, they have generated much recent interest. Deep connections exist with particle physics models of relativistic chiral fermions, and, despite their gaplessness, to solid-state topological and Chern insulators. Their characteristic electronic properties lead to protected surface states and novel responses to applied electric and magnetic fields. The theoretical foundations of these phases, their proposed realizations in solid-state systems, and recent experiments on candidate materials as well as their relation to other states of matter are reviewed.

Weyl and Dirac semimetals in three-dimensional solids

The Hall conductance of a two-dimensional electron gas has been studied in a uniform magnetic field and a periodic substrate potential $U$. The Kubo formula is written in a form that makes apparent the quantization when the Fermi energy lies in a gap. Explicit expressions have been obtained for the Hall conductance for both large and small $\frac{U}{\ensuremath{\hbar}{\ensuremath{\omega}}_{c}}$.

https://digitalcommons.uri.edu/cgi/viewcontent.cgi?article=1322&context=phys_facpubs

Quantized Hall conductance in a two-dimensional periodic potential

A one-dimensional Schr\"odinger equation in a discontinuous quasiperiodic potential is reduced to a recursion relation for transfer matrices and then to one for traces of these matrices. When the potential is periodic, the bandwidth goes to zero as an algebraic function of the period with a critical index which depends upon the potential strength. This critical index is also evaluated as the solution to an escape-rate problem for the recursion relations.

http://jfi.uchicago.edu/~leop/SciencePapers/Old%20Science%20Papers/Localization%20Problem%20in%20One%20Dimension%20Mapping%20and%20Escape.pdf

Localization Problem in One Dimension: Mapping and Escape

Topological invariant and the quantization of the Hall conductance

The electronic properties of a tight-binding model which possesses two types of hopping matrix element (or on-site energy) arranged in a Fibonacci sequence are studied. The wave functions are either self-similar (fractal) or chaotic and show ``critical'' (or ``exotic'') behavior. Scaling analysis for the self-similar wave functions at the center of the band and also at the edge of the band is performed. The energy spectrum is a Cantor set with zero Lebesque measure. The density of states is singularly concentrated with an index ${\ensuremath{\alpha}}_{E}$ which takes a value in the range [${\ensuremath{\alpha}}_{E}^{\mathrm{min}}$,${\ensuremath{\alpha}}_{E}^{\mathrm{max}}$]. The fractal dimensions f(${\ensuremath{\alpha}}_{E}$) of these singularities in the Cantor set are calculated. This function f(${\ensuremath{\alpha}}_{E}$) represents the global scaling properties of the Cantor-set spectrum.

Critical wave functions and a Cantor-set spectrum of a one-dimensional quasicrystal model

An experiment to probe the (quasi)localization of the photon is proposed, in which optical layers are constructed following the Fibonacci sequence. The transmission coefficient has a rich structure as a function of the wavelength of light and, in fact, is multifractal. For particular wavelengths for which the resonance condition is satisfied, the light propagation has scaling with respect to the number of layers, as well as an interesting fluctuation.

Mahito Kohmoto

Papers

Quantized Hall conductance in a two-dimensional periodic potential

Localization Problem in One Dimension: Mapping and Escape

Topological invariant and the quantization of the Hall conductance

Critical wave functions and a Cantor-set spectrum of a one-dimensional quasicrystal model

Localization of optics: Quasiperiodic media.