Leu-M

A review on polymeric hydrogel membranes for wound dressing applications: PVA-based hydrogel dressings

Classification, processing and application of hydrogels: A review.

The bioink: A comprehensive review on bioprintable materials.

Hydrogels, due to their excellent biochemical and mechnical property, have shown attractive advantages in the field of wound dressings. However, a comprehensive review of the functional hydrogel as a wound dressing is still lacking. This work first summarizes the skin wound healing process and relates evaluation parameters and then reviews the advanced functions of hydrogel dressings such as antimicrobial property, adhesion and hemostasis, anti-inflammatory and anti-oxidation, substance delivery, self-healing, stimulus response, conductivity, and the recently emerged wound monitoring feature, and the strategies adopted to achieve these functions are all classified and discussed. Furthermore, applications of hydrogel wound dressing for the treatment of different types of wounds such as incisional wound and the excisional wound are summarized. Chronic wounds are also mentioned, and the focus of attention on infected wounds, burn wounds, and diabetic wounds is discussed. Finally, the future directions of hydrogel wound dressings for wound healing are further proposed.

Functional Hydrogels as Wound Dressing to Enhance Wound Healing.

Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: Characterization and bio-evaluation

Physically crosslinked poly(vinyl alcohol)-hydroxyethyl starch blend hydrogel membranes: Synthesis and characterization for biomedical applications

Fabrication of biodegradable gelatin/chitosan/cinnamaldehyde crosslinked membranes for antibacterial wound dressing applications

Abstract This study aims to prepare novel cross-linked antimicrobial membranes composed of PVA-Aloe vera hydrogels using novel physically cross-linked method via transforming PVA to high crystalline structure using propanol. Curcumin was incorporated to improve the membrane biological properties; while gentamycin improved sharply antimicrobial properties. PVA-Aloe vera hydrogel membranes were analyzed by FTIR, SEM, XRD and TGA measurements for characterizing resultant cross-linked membranes. Physicochemical measurements, e.g., swelling and mechanical stability were assessed for further studying the dressings. Antibacterial activity of cross-linked PVA-Aloe vera-curcumin membranes was tested using five bacterial strains. Results showed that high Aloe vera content in cross-linked membranes has insignificant impact on the release of gentamicin. Adult Wister Albino rats were used to test membrane’s ability for improving the wound healing rate in vivo. In vivo findings showed that PVA/Aloe vera/curcumin membranes dramatically reduced the size of mouse full-thickness wounds, as indicated by a decrease in the wound size. Furthermore, histological tests of wounds dressed with membranes revealed a significant re-epithelialization; compared to wounds treated with cotton gauze and PVA/Aloe vera dressings without curcumin, showing curcumin’s efficacy. These results refer to PVA-Aloe vera-curcumin membrane has exceptional wound healing and skin regeneration capacity. 

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Novel Physically Cross-Linked Curcumin-Loaded PVA/Aloe vera Hydrogel Membranes for Acceleration of Topical Wound Healing: In Vitro and In Vivo Experiments

Mahmoud A. El-Meligy

Papers

Poly (vinyl alcohol)-alginate physically crosslinked hydrogel membranes for wound dressing applications: Characterization and bio-evaluation

Physically crosslinked poly(vinyl alcohol)-hydroxyethyl starch blend hydrogel membranes: Synthesis and characterization for biomedical applications

Fabrication of biodegradable gelatin/chitosan/cinnamaldehyde crosslinked membranes for antibacterial wound dressing applications

Novel Physically Cross-Linked Curcumin-Loaded PVA/Aloe vera Hydrogel Membranes for Acceleration of Topical Wound Healing: In Vitro and In Vivo Experiments

Wound dressing membranes based on immobilized Anisaldehyde onto (chitosan-GA-gelatin) copolymer: In-vitro and in-vivo evaluations.