M
Mahmoud Huleihel
Researcher at Ben-Gurion University of the Negev
Publications - 269
Citations - 7727
Mahmoud Huleihel is an academic researcher from Ben-Gurion University of the Negev. The author has contributed to research in topics: Spermatogenesis & Virus. The author has an hindex of 46, co-authored 255 publications receiving 6832 citations. Previous affiliations of Mahmoud Huleihel include National Institutes of Health & French Institute of Health and Medical Research.
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Journal ArticleDOI
Mutational activation of c-raf-1 and definition of the minimal transforming sequence.
Gisela Heidecker,Mahmoud Huleihel,John L. Cleveland,Walter Kolch,Thomas William Beck,Patricia Lloyd,T. Pawson,Ulf R. Rapp +7 more
TL;DR: Oncogenic activation of the Raf kinase can be achieved by removal of CR1 and CR2 or by steric distortion and requires retention of an active kinase domain, consistent with a protein structure model for the nonstimulated enzyme in which the active site is buried within the protein.
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Specific neurodevelopmental damage in mice offspring following maternal inflammation during pregnancy.
TL;DR: Maternal inflammation specifically impaired distinct forms of learning and memory, but not motor function or exploration in the adult offspring, which may suggest particular sensitivity of the hippocampus and other associated brain regions to inflammatory factors during late embryonic development.
Journal Article
Regulation of spermatogenesis by paracrine/autocrine testicular factors.
Mahmoud Huleihel,Eitan Lunenfeld +1 more
TL;DR: Under pathological conditions the levels of pro-inflammatory cytokines are increased and negatively affected spermatogenesis, and the expression levels and the mechanisms involved in the regulation of testicular paracrine/autocrine factors should be considered in future therapeutic strategies for male infertility.
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Involvement of Tumor Necrosis Factor Alpha in Hippocampal Development and Function
TL;DR: It is reported here that TNFalpha is involved in the regulation of morphological development in the hippocampus and specifically improved performance of affected mice in behavioral tasks related to spatial memory.
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New horizons for in vitro spermatogenesis? An update on novel three-dimensional culture systems as tools for meiotic and post-meiotic differentiation of testicular germ cells
Jan-Bernd Stukenborg,Stefan Schlatt,Manuela Simoni,Ching-Hei Yeung,Mahmoud Abu Elhija,C.M. Luetjens,Mahmoud Huleihel,Joachim Wistuba +7 more
TL;DR: For the first time, it is demonstrated that pre-meiotic male germ cells obtained from immature mice pass through meiosis in vitro and appear independent from the matrix in a 3D culture environment.