Manica Negahdaripour

TL;DR: The intracellular delivery of ADI and combination therapy seem to be the future strategies in the treatment of arginine auxotrophic cancers.

TL;DR: Peptide synthesis has become accessible, and advances in peptide engineering, sequencing technologies, and structural bioinformatics have resulted in the rational designing of novel peptides which would lead to the more prominent roles of peptides in the mentioned areas.

TL;DR: Treatment of hepatocarcinoma cell line (Hep‐G2) with 1–500 µg/mL concentrations of Fe‐EPS nanoparticles caused 40% increase in the cell viability, which indicated that the biosynthesized nanoparticles were nontoxic and biocompatible.

TL;DR: Structural and immunological computational results indicated the potential of the designed construct for proper stimulation of cellular and humoral immune responses against BC and the candidate vaccine could be introduced for BC therapy after the efficacy of it was confirmed by in vivo and in vitro immunological assays.

TL;DR: Investigating the most important signaling pathways activated by coronaviruses to better understand the viral pathogenesis and host immune responses found that administration of interferons or interferon-inducing agents in a prophylactic manner or at early stages of the disease, could mimic the effective antiviral responses against SARS-CoV-2 and reduce the disease severity.