M
Manikandan Jayapal
Researcher at National University of Singapore
Publications - 12
Citations - 942
Manikandan Jayapal is an academic researcher from National University of Singapore. The author has contributed to research in topics: DNA repair & DNA damage. The author has an hindex of 10, co-authored 11 publications receiving 849 citations.
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Journal ArticleDOI
Expression profile of immune response genes in patients with Severe Acute Respiratory Syndrome
Renji Reghunathan,Manikandan Jayapal,Li Yang Hsu,Hiok Hee Chng,Dessmon Y. H. Tai,Bernard P. Leung,Alirio J. Melendez +6 more
TL;DR: This study shows for the first time how the immune system responds to the SARS infection, and opens new possibilities for designing new diagnostics and treatments for this new life-threatening disease.
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Effects of an integrated yoga program in modulating psychological stress and radiation-induced genotoxic stress in breast cancer patients undergoing radiotherapy.
Birendranath Banerjee,H.S. Vadiraj,Amritanshu Ram,Raghavendra M Rao,Manikandan Jayapal,Kodaganur S. Gopinath,B. Ramesh,Nalini Rao,Ajay Kumar,Nagarathna Raghuram,Sridevi Hegde,H.R. Nagendra,M. Prakash Hande +12 more
TL;DR: Effects of an integrated yoga program in modulating perceived stress levels, anxiety, as well as depression levels and radiation-induced DNA damage were studied in 68 breast cancer patients undergoing radiotherapy.
Journal ArticleDOI
Thymoquinone Induces Telomere Shortening, DNA Damage and Apoptosis in Human Glioblastoma Cells
Resham L Gurung,Shi Ni Lim,Aik Kia Khaw,Jasmine Fen Fen Soon,Kirthan Shenoy,Safiyya Mohamed Ali,Manikandan Jayapal,Swaminathan Sethu,Rajamanickam Baskar,M. Prakash Hande +9 more
TL;DR: Thymoquinone could be useful as a potential chemotherapeutic agent in the management for brain tumours and induces DNA damage, telomere attrition by inhibiting telomerase and cell death in glioblastoma cells.
Journal ArticleDOI
DNA microarray technology for target identification and validation.
TL;DR: The present article reviews the principles and technological concerns, as well as the steps involved in obtaining and analysing of data, of microarray technology and presents a broad overview of this rapidly growing field.
Journal ArticleDOI
Genome-wide gene expression profiling of human mast cells stimulated by IgE or FcεRI-aggregation reveals a complex network of genes involved in inflammatory responses
Manikandan Jayapal,Hwee Kee Tay,Renji Reghunathan,Liang Zhi,Kah Kiong Chow,Mary Rauff,Alirio J. Melendez +6 more
TL;DR: This report represents a substantial advance in the understanding of the genome wide effects triggered by "passive sensitization" or active stimulation of human mast cells, supporting mast cells' potential involvement in a wide range of inflammatory responses.