Manoj M. Varma

TL;DR: In this paper, a laser beam is sequentially directed onto each of the plurality of targets, the laser being positioned relative to the substrate such that when the beam is directed onto a target, a first half of the beam was reflected back to the laser from the wall of the target and a second half of a beam is reflected back from the surface of the substrate adjacent the target, and the laser combines the first and second reflected halves to produce a diffraction signal that has a first value when an analyte is not bound to the receptor coating associated with a target and second value

TL;DR: This work fabricated interferometric microstructures on silicon and on dielectric mirror disks to demonstrate the basic principles of the BioCD and detected the presence of immobilized anti-mouse IgG and the specific binding of 10 femtomol of mouse IgG at a sampling rate of 100 kilo-samples/s, while also demonstrating negligible non-specific binding.

TL;DR: This BioCD has the potential to be applied as a spinning-disk interferometric immunoassay and biosensor and strong molecular recognition is demonstrated by the absence of binding to nontarget molecules but strong signal change in response to a specific antigen.

TL;DR: In this article, the authors used a finite element model to calculate the Bragg wavelength change as a function of thickness and refractive index of the adsorbing molecular layer and compared the model with the real-time, in-situ measurement of electrostatic layer-by-layer assembly of weak polyelectrolytes on the silica surface of EFBGs.

TL;DR: A novel gas sensor based on clad-etched Fiber Bragg Grating with polyallylamine-amino-carbon nanotube coated on the surface of the core for detecting the concentrations of CO2 gas at room temperature, in ppm levels over a wide range.