Showing papers by "Manuel Monreal published in 1990"
TL;DR: The findings suggest that LMWH may have a lower osteopenic effect than that of conventional heparin, and statistically significant differences have been found in ash contents.
Abstract: In an animal model, the effect of a high dose of conventional heparin (2 IU/g s.c. twice a day) and a low-molecular-weight heparin (LMWH; Fragmin, 1 anti-Xa U/g once a day) was compared with that of placebo on the mineral bone mass in the femur of rats. After 33 days of treatment no differences were found in the weight of the femur. But heparin-treated rats exhibited a lower density (1,249 ± 0.046 g/ml as compared with that in control rats (p = 0.00007) and also in LMWH-treated rats (p = 0.001). Similarly, statistically significant differences have been found in ash contents. They were higher in control rats than in heparin-treated rats (p = 0.0002), and also slightly higher than in LMWH-treated rats (p = 0.01). Our findings suggest that LMWH may have a lower osteopenic effect than that of conventional heparin.
59 citations
Journal Article•
TL;DR: Retrospective study about the frequency of hemorrhagic complications in the treatment of venous thrombosis and/o pulmonary embolism, with heparin, with intermittently administered by endovenous way and controlled during the ten first days.
Abstract: Retrospective study about the frequency of hemorrhagic complications (258 patients) in the treatment of venous thrombosis and/o pulmonary embolism, with heparin. Heparin was intermittently administered by endovenous way and controlled during the ten first days. Mostly of the big hemorrhages happened between the seventh and the tenth day, in digestive and urinary system mainly.
2 citations
TL;DR: It is suggested that real-time B-mode US should be considered as the method of choice in patients with suspected DVT, mainly in those cases (as in pregnant women) in whom extrinsic compression may induce false-positive results with the remainder noninvasive methods.
Abstract: We suggest that real-time B-mode US should be considered as the method of choice in patients with suspected DVT, mainly in those cases (as in pregnant women) in whom extrinsic compression may induce false-positive results with the remainder noninvasive methods
1 citations