M
Manuel O. Landázuri
Researcher at Autonomous University of Madrid
Publications - 62
Citations - 4947
Manuel O. Landázuri is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Hypoxia-inducible factors & Transcription factor. The author has an hindex of 37, co-authored 62 publications receiving 4615 citations. Previous affiliations of Manuel O. Landázuri include Services Hospital & University of California, Los Angeles.
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Journal ArticleDOI
NDUFA4 Is a Subunit of Complex IV of the Mammalian Electron Transport Chain
Eduardo Balsa,Eduardo Balsa,Ricardo Marco,Ester Perales-Clemente,Radek Szklarczyk,Enrique Calvo,Manuel O. Landázuri,José Antonio Enríquez,José Antonio Enríquez +8 more
TL;DR: It is shown that NDUFA4, formerly considered a constituent of NADH Dehydrogenase (CI), is instead a component of the cytochrome c oxidase (CIV) and should be considered a candidate gene for CIV rather than CI deficiencies in humans.
Journal ArticleDOI
Regulation of Endothelial Cell Motility by Complexes of Tetraspan Molecules CD81/TAPA-1 and CD151/PETA-3 with α3β1 Integrin Localized at Endothelial Lateral Junctions
María Yáñez-Mó,Arantzazu Alfranca,Carlos Cabañas,Mónica Marazuela,Reyes Tejedor,M. Ángeles Ursa,Leonie K. Ashman,Manuel O. Landázuri,Francisco Sánchez-Madrid +8 more
TL;DR: Results indicate that CD81/TAPA-1 and CD151/PETA-3 tetraspan molecules are components of the endothelial lateral junctions implicated in the regulation of cell motility, either directly or by modulation of the function of the associated integrin heterodimers.
Journal ArticleDOI
Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity
Daniel Tello,Eduardo Balsa,Bárbara Acosta-Iborra,Esther Fuertes-Yebra,Ainara Elorza,Angel Ordoñez,María Corral-Escariz,Inés Soro,Elia López-Bernardo,Ester Perales-Clemente,Antonio Martínez-Ruiz,José Antonio Enríquez,José Antonio Enríquez,Julián Aragonés,Susana Cadenas,Manuel O. Landázuri +15 more
TL;DR: Cutting mitochondrial Complex I activity via NDUFA4L2 appears to be an essential element in the mitochondrial reprogramming induced by HIF-1, which limits the intracellular ROS production under low-oxygen conditions.
Journal ArticleDOI
Hypoxia induces the activation of the phosphatidylinositol 3-kinase/Akt cell survival pathway in PC12 cells: protective role in apoptosis.
Miguel Alvarez-Tejado,Salvador Naranjo-Suarez,Concepción Jiménez,Ana C. Carrera,Manuel O. Landázuri,Luis del Peso +5 more
TL;DR: Reduced oxygen tension regulates apoptosis in PC12 cells through activation of the PI3K/Akt survival pathway, which is detected after 3–4 h of hypoxic or deferoxamine treatment and is sustained while hypoxic conditions are maintained.
Journal ArticleDOI
VLA-3: a novel polypeptide association within the VLA molecular complex: cell distribution and biochemical characterization.
Francisco Sánchez-Madrid,Manuel O. Landázuri,Gloria Morago,M Cebrián,Augustín Acevedo,Carmelo Bernabeu +5 more
TL;DR: The results suggest that the association between the 165‐ and 80‐kDa subunits diminishes during the activation process, and that the epitopes recognized by the HP mAb are located on the 80-kDa protein, which has been termed VLA‐3.