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Antonio Martínez-Ruiz
Researcher at Autonomous University of Madrid
Publications - 89
Citations - 4415
Antonio Martínez-Ruiz is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Oxidative stress & Nitric oxide. The author has an hindex of 37, co-authored 77 publications receiving 3879 citations. Previous affiliations of Antonio Martínez-Ruiz include Carlos III Health Institute & Spanish National Research Council.
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Journal ArticleDOI
Nitric oxide signaling: Classical, less classical, and nonclassical mechanisms
TL;DR: An integrated systems biology approach to the comprehension of NO function will probably emerge in the near future, due to the formation of NO-induced posttranslational modifications (PTMs) which might have important implications for cell respiration and intermediary metabolism.
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S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities.
Antonio Martínez-Ruiz,Laura Villanueva,Cecilia González de Orduña,Daniel Lopez-Ferrer,María Ángeles Higueras,Carlos Tarin,Ignacio Rodríguez-Crespo,Jesús Vázquez,Santiago Lamas +8 more
TL;DR: It is suggested that S-nitrosylation may functionally regulate the general activities of Hsp90 and provide a feedback mechanism for limiting eNOS activation.
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Reactive oxygen species, nutrition, hypoxia and diseases: Problems solved?
Agnes Görlach,Elitsa Y. Dimova,Andreas Petry,Antonio Martínez-Ruiz,Pablo Hernansanz-Agustín,Anabela P. Rolo,Carlos M. Palmeira,Thomas Kietzmann +7 more
TL;DR: In this review, aspects and problems on the role of intracellular ROS formation and nutrition with the link to diseases and their problematic therapeutical issues are discussed.
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Induction of the Mitochondrial NDUFA4L2 Protein by HIF-1α Decreases Oxygen Consumption by Inhibiting Complex I Activity
Daniel Tello,Eduardo Balsa,Bárbara Acosta-Iborra,Esther Fuertes-Yebra,Ainara Elorza,Angel Ordoñez,María Corral-Escariz,Inés Soro,Elia López-Bernardo,Ester Perales-Clemente,Antonio Martínez-Ruiz,José Antonio Enríquez,José Antonio Enríquez,Julián Aragonés,Susana Cadenas,Manuel O. Landázuri +15 more
TL;DR: Cutting mitochondrial Complex I activity via NDUFA4L2 appears to be an essential element in the mitochondrial reprogramming induced by HIF-1, which limits the intracellular ROS production under low-oxygen conditions.
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S-nitrosylation: a potential new paradigm in signal transduction
TL;DR: The chemical basis of S-nitrosylation of cysteines compared with other protein modifications related to nitric oxide, as well as the kind of specificity the authors can expect from it are reviewed.