M
Mar Larrosa
Researcher at European University of Madrid
Publications - 80
Citations - 7148
Mar Larrosa is an academic researcher from European University of Madrid. The author has contributed to research in topics: Gut flora & Resveratrol. The author has an hindex of 39, co-authored 73 publications receiving 5928 citations. Previous affiliations of Mar Larrosa include University of Florence & Spanish National Research Council.
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Journal ArticleDOI
Biological significance of urolithins, the gut microbial ellagic Acid-derived metabolites: the evidence so far.
TL;DR: Preliminary evidence is shown of the anti-inflammatory, anticarcinogenic, antiglycative, antioxidant, and antimicrobial effects of urolithins, supporting their potential contribution to the health effects attributed to pomegranate and ellagitannin-rich foods.
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The dietary hydrolysable tannin punicalagin releases ellagic acid that induces apoptosis in human colon adenocarcinoma Caco-2 cells by using the mitochondrial pathway.
TL;DR: This study suggests that the anticarcinogenic effect of dietary ETs could be mainly due to their hydrolysis product, EA, which induced apoptosis via mitochondrial pathway in colon cancer Caco-2 cells but not in normal colon cells.
Journal ArticleDOI
Anti-inflammatory properties of a pomegranate extract and its metabolite urolithin-A in a colitis rat model and the effect of colon inflammation on phenolic metabolism
Mar Larrosa,Antonio González-Sarrías,María J. Yáñez-Gascón,María V. Selma,María Azorín-Ortuño,Simona Toti,Francisco A. Tomás-Barberán,Piero Dolara,Juan Carlos Espín +8 more
TL;DR: The results suggest that UROA could be the most active anti-inflammatory compound derived from pomegranate ingestion in healthy subjects, whereas in colon inflammation, the effects could be due to the nonmetabolized ellagitannin-related fraction.
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Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence.
Joao Tomé-Carneiro,Mar Larrosa,Antonio González-Sarrías,Francisco A. Tomás-Barberán,María Teresa García-Conesa,Juan Carlos Espín +5 more
TL;DR: This review will focus on the currently available evidence regarding resveratrol’s effects on humans obtained from randomized clinical trials and provide a critical outlook for further research on this molecule that is evolving from a minor dietary compound to a possible multi-target therapeutic drug.
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Ellagitannins, ellagic acid and vascular health
TL;DR: The role of ellagitannins and ellagic acid on vascular health is critically discussed, with good evidence supporting the vascular effects in vitro and the evidence on animal models or humans is much scarcer.