M
Marcel M. Daadi
Researcher at Texas Biomedical Research Institute
Publications - 52
Citations - 1712
Marcel M. Daadi is an academic researcher from Texas Biomedical Research Institute. The author has contributed to research in topics: Neural stem cell & Induced pluripotent stem cell. The author has an hindex of 15, co-authored 50 publications receiving 1553 citations. Previous affiliations of Marcel M. Daadi include Stanford University & University of Texas Health Science Center at San Antonio.
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Journal ArticleDOI
Cell Transplantation Therapy for Stroke
TL;DR: A growing number of studies highlight the potential of stem cell transplantation as a novel therapeutic approach for stroke, and the need to determine parameters that are critical for transplantation success is emphasized.
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Adherent self-renewable human embryonic stem cell-derived neural stem cell line: functional engraftment in experimental stroke model.
TL;DR: The SD56 human neural stem cells derived under the reported conditions are stable, do not form tumors in vivo and enable functional recovery after stroke, indicating that this hNSC line may offer a renewable, homogenous source of neural cells that will be valuable for basic and translational research.
Journal ArticleDOI
Human Neural Stem Cell Grafts Modify Microglial Response and Enhance Axonal Sprouting in Neonatal Hypoxic–Ischemic Brain Injury
Marcel M. Daadi,Alexis S. Davis,Ahmet Arac,Zongjin Li,Anne-Lise Maag,Rishi Bhatnagar,Kewen Jiang,Guohua Sun,Joseph C. Wu,Gary K. Steinberg +9 more
TL;DR: The results suggest that human neural stem cell transplants enhance endogenous brain repair through multiple modalities in response to HI, and reveal upregulation of genes involved in neurogenesis, gliogenesis, and neurotrophic support.
Journal ArticleDOI
Molecular and magnetic resonance imaging of human embryonic stem cell-derived neural stem cell grafts in ischemic rat brain.
Marcel M. Daadi,Zongjin Li,Ahmet Arac,Brad A. Grueter,Marc Sofilos,Robert C. Malenka,Joseph C. Wu,Gary K. Steinberg +7 more
TL;DR: The data suggest that the combination of BLI and MRI modalities provides reliable real-time monitoring of cell fate, and this study used bioluminescence and magnetic resonance imaging to visualize the fate of grafted human embryonic stem cell (hESC)-derived human neural stem cells (hNSCs) in stroke-damaged rat brain.
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Embryonic MGE precursor cells grafted into adult rat striatum integrate and ameliorate motor symptoms in 6-OHDA-lesioned rats
Verónica Martínez-Cerdeño,Stephen C. Noctor,Ana Espinosa,Jeanelle Ariza,Philip R.L. Parker,Samantha Orasji,Marcel M. Daadi,Krystof S. Bankiewicz,Arturo Alvarez-Buylla,Arnold R. Kriegstein +9 more
TL;DR: It is suggested that MGE cell transplantation into the striatum is a promising approach to investigate the potential benefits of remodeling basal ganglia circuitry in neurodegenerative diseases.