M
Marcia Martins Reis
Researcher at University of São Paulo
Publications - 37
Citations - 1179
Marcia Martins Reis is an academic researcher from University of São Paulo. The author has contributed to research in topics: Antigen & Inflammation. The author has an hindex of 15, co-authored 36 publications receiving 1116 citations.
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Journal ArticleDOI
Pathophysiology of the heart in Chagas' disease: current status and new developments.
TL;DR: In the present review, remarkable historical data on Chagas' disease studies putting special emphasis on histopathological findings and pathogenetic theories as well as recent discoveries based on the use of advanced modern technologies in pathology and immunology are summarized.
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Correlation between Trypanosoma cruzi parasitism and myocardial inflammatory infiltrate in human chronic chagasic myocarditis: Light microscopy and immunohistochemical findings.
Maria de Lourdes Higuchi,Thales de Brito,Marcia Martins Reis,Alfredo Barbosa,Giovanni Bellotti,Antonio Carlos Pereira-Barreto,Fulvio Pileggi +6 more
TL;DR: The striking correlation between the presence of T. cruzi antigen(s) with the severity of site of the inflammatory infiltrate supports a direct role for the parasite in the perpetuation of myocardial inflammation in Chagas' disease.
Journal ArticleDOI
Anin SituQuantitative Immunohistochemical Study of Cytokines and IL-2R+in Chronic Human Chagasic Myocarditis: Correlation with the Presence of MyocardialTrypanosoma cruziAntigens
Marcia Martins Reis,Maria de Lourdes Higuchi,Luiz Alberto Benvenuti,Vera Demarchi Aiello,Paulo Sampaio Gutierrez,Giovanni Bellotti,Fulvio Pileggi +6 more
TL;DR: The results suggest that cytokines, as they occur in other infectious diseases, play a fundamental role in the control of T. cruzi in chronic human chagasic disease.
Journal ArticleDOI
Prognostic Values of Stromal Proportion and PCNA, Ki-67, and p53 Proteins in Patients with Resected Adenocarcinoma of the Lung
Léa Maria Macruz Ferreira Demarchi,Marcia Martins Reis,Suely Aparecida Pinheiro Palomino,Cecília Farhat,Teresa Yae Takagaki,Ricardo Beyruti,Paulo Hilário Nascimento Saldiva,Vera Luiza Capelozzi +7 more
TL;DR: T tumor stromal proportion and immunohistochemical detection of p53 protein, controlled for sex, T stage, and N stage, may be of critical value in the evaluation of recurrence of lung adenocarcinoma, serving as indicators for a more accurate prognosis.
Journal ArticleDOI
Locally produced survival cytokines IL-15 and IL-7 may be associated to the predominance of CD8+ T cells at heart lesions of human chronic Chagas disease cardiomyopathy.
Simone G. Fonseca,Simone G. Fonseca,Marcia Martins Reis,Verônica Coelho,Verônica Coelho,Luciana Gabriel Nogueira,Luciana Gabriel Nogueira,Sandra Maria Monteiro,Eliane Conti Mairena,Fernando Bacal,E A Bocchi,Luiza Guilherme,Luiza Guilherme,X. X. Zheng,Foo Y. Liew,Maria de Lourdes Higuchi,Jorge Kalil,Jorge Kalil,Edecio Cunha-Neto,Edecio Cunha-Neto +19 more
TL;DR: It was found that IL‐7 and IL‐15 were superior to IL‐2 in the expansion and viability of CD8+ T cells from both PBMC and heart‐infiltrating T‐cell lines from CCC patients, and the combination of the three cytokines showed synergy effects.