Marco Biggiogera

TL;DR: Zc3h13 (zinc finger CCCH domain-containing protein 13)/Flacc [Fl(2)d-associated complex component] is identified as a novel interactor of m6A methyltransferase complex components in Drosophila and mice and it is demonstrated that Flacc promotes m 6A deposition by bridging Fl( 2)d to the mRNA-binding factor Nito.

TL;DR: It is shown that neurospheres and neurosphere-forming cells are morphologically and functionally heterogeneous and may contribute to the understanding of the morphogenesis of the neuro Spheres, particularly as this process relates to the high environmental adaptability of the NSCs and the reported existence of different subpopulations of neural stem cells.

TL;DR: The analysis of the presence and fate of the p89 proteolytic fragment revealed that PARP-1 proteolysis by caspases is concomitant with poly(ADP-ribose) synthesis and that p89 migrates from the nucleus into the cytoplasm in late apoptotic cells with advanced nuclear fragmentation.

TL;DR: The intranucleolar distribution of phosphoproteins B23 and C23 was visualized simultaneously by post-embedding immunoelectron microscopy in HeLa cell nucleoli, using specific antibodies to suggest that other unidentified components must be responsible for the silver staining observed in the fibrillar centers of interphase nucleoli.

TL;DR: The observations suggest that there is no direct relationship between the occurrence of silver staining and the distribution of protein B23 or nucleolin and neither the localization of the two above proteins nor silverStaining are unequivocally related to the nucleolar activity.