M
Marco Oldiges
Researcher at Forschungszentrum Jülich
Publications - 119
Citations - 3972
Marco Oldiges is an academic researcher from Forschungszentrum Jülich. The author has contributed to research in topics: Corynebacterium glutamicum & Bioprocess. The author has an hindex of 33, co-authored 107 publications receiving 3443 citations. Previous affiliations of Marco Oldiges include RWTH Aachen University & University of Siegen.
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Journal ArticleDOI
Simultaneous determination of multiple intracellular metabolites in glycolysis, pentose phosphate pathway and tricarboxylic acid cycle by liquid chromatography-mass spectrometry
TL;DR: Most of the intracellular metabolites were found within the detection range and the relative standard deviations of the measurements were smaller than 5.65% (n=5) for a cell extract sample.
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Metabolomics: current state and evolving methodologies and tools.
TL;DR: Together with the other more established omics technologies, metabolomics will strengthen its claim to contribute to the detailed understanding of the in vivo function of gene products, biochemical and regulatory networks and, even more ambitious, the mathematical description and simulation of the whole cell in the systems biology approach.
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Metabolic flux analysis at ultra short time scale: isotopically non-stationary 13C labeling experiments.
TL;DR: It is shown that significant new information with respect to flux identifiability, non-measurable pool sizes, data consistency, or large storage pools can be taken from the novel kind of experimental data.
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Corynebacterium glutamicum tailored for high-yield L-valine production
Bastian Blombach,Mark Schreiner,Mark Schreiner,Tobias Bartek,Marco Oldiges,Bernhard J. Eikmanns +5 more
TL;DR: A second generation of high-yield L-valine producers was constructed by successive deletion of the genes encoding pyruvate:quinone oxidoreductase, phosphoglucose isomerase, and pyruVate carboxylase and overexpression of ilvBNCE.
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l-Valine Production with Pyruvate Dehydrogenase Complex-Deficient Corynebacterium glutamicum
Bastian Blombach,Mark Schreiner,Jiří Holátko,Tobias Bartek,Marco Oldiges,Bernhard J. Eikmanns +5 more
TL;DR: Corynebacterium glutamicum was engineered for the production of l-valine from glucose by deletion of the aceE gene encoding the E1p enzyme of the pyruvate dehydrogenase complex and additional overexpression of the ilvBNCE genes encoding the l-Valine biosynthetic enzymes acetohydroxyacid synthase, isomeroreductase, and transaminase B.