M
Maria E. Sabbatini
Researcher at Georgia Regents University
Publications - 29
Citations - 674
Maria E. Sabbatini is an academic researcher from Georgia Regents University. The author has contributed to research in topics: Natriuretic peptide & Atrial natriuretic peptide. The author has an hindex of 15, co-authored 28 publications receiving 578 citations. Previous affiliations of Maria E. Sabbatini include University of Buenos Aires & University of Michigan.
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Journal ArticleDOI
The MLL1-H3K4me3 Axis-Mediated PD-L1 Expression and Pancreatic Cancer Immune Evasion.
Chunwan Lu,Amy V. Paschall,Huidong Shi,Natasha M. Savage,Jennifer L. Waller,Maria E. Sabbatini,Nicholas H. Oberlies,Cedric J. Pearce,Kebin Liu,Kebin Liu +9 more
TL;DR: The Fas-FasL/CTLs and the MLL1-H3K4me3-PD-L1 axis play contrasting roles in pancreatic cancer immune surveillance and evasion.
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Small G proteins as key regulators of pancreatic digestive enzyme secretion
TL;DR: Emerging evidence indicates that small G proteins regulate a number of steps in the secretion of pancreatic acinar cells and most evidence suggests that Rab3D and Rab27B play a role in tethering the secretory granule to its target membrane.
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Rap1 Activation Plays a Regulatory Role in Pancreatic Amylase Secretion
TL;DR: GTP-Rap1 activation not only mediates the cAMP-evoked response via Epac1 but is also involved in CCK- and carbachol-induced amylase release, with their action most likely mediated by CalDAG-GEF III.
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Atrial natriuretic factor stimulates exocrine pancreatic secretion in the rat through NPR-C receptors
Maria E. Sabbatini,Alberto R Villagra,Carlos Davio,Marcelo S. Vatta,Belisario E. Fernández,Liliana G. Bianciotti +5 more
TL;DR: Findings support that ANF exerts a stimulatory effect on pancreatic exocrine secretion mediated by NPR-C receptors coupled to the phosphoinositide pathway.
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Contrasting Roles of H3K4me3 and H3K9me3 in Regulation of Apoptosis and Gemcitabine Resistance in Human Pancreatic Cancer Cells
Chunwan Lu,Chunwan Lu,Dafeng Yang,Dafeng Yang,Maria E. Sabbatini,Aaron H. Colby,Mark W. Grinstaff,Nicholas H. Oberlies,Cedric J. Pearce,Kebin Liu,Kebin Liu +10 more
TL;DR: Test the hypothesis that epigenetic dysregulation of apoptosis mediators underlies PDAC resistance to gemcitabine and determined that PDAC cells use H3K4me3 to activate Bcl-x, FLIP and Mcl-1, and H 3K9me 3 to silence Bak, Bax and Bim to acquire an apoptosis-resistant phenotype.