Showing papers in "Journal of Biological Chemistry in 2008"

TL;DR: Loss of expression of the miR-200 family members may play a critical role in the repression of E-cadherin by ZEB1 and ZEB2 during EMT, thereby enhancing migration and invasion during cancer progression.

TL;DR: This study demonstrates that mitochondrial autophagy is induced by hypoxia, that this process requires the Hypoxia-dependent factor-1-dependent expression of BNIP3 and the constitutive expression of Beclin-1 and Atg5, and that in cells subjected to prolonged hypoxIA, mitochondrial autphagy is an adaptive metabolic response which is necessary to prevent increased levels of reactive oxygen species and cell death.

TL;DR: Modulation of sclerostin levels appears to be a finely tuned mechanism by which osteocytes coordinate regional and local osteogenesis in response to increased mechanical stimulation, perhaps via releasing the local inhibition of Wnt/Lrp5 signaling.

TL;DR: The tumor suppressor protein Programmed Cell Death 4 (PDCD4) is regulated by miR-21 and it is demonstrated that PDCD4 is a functionally important target for mi R-21 in breast cancer cells.

TL;DR: Molecular characterization of the secretases involved in Aβ production has facilitated cell biological investigations on APP processing and advanced efforts to model AD pathogenesis in animal models.

TL;DR: Evidence is provided that mitochondria of PD-vulnerable substantia nigra and striatum but not cerebellum from PD subjects showed significant accumulation of α-synuclein and decreased complex I activity, which provides evidence that mitochondrial accumulated α- synuclein may interact with complex I and interfere with its functions.

TL;DR: It is concluded that miR-210 up-regulation is a crucial element of endothelial cell response to hypoxia, affecting cell survival, migration, and differentiation.

TL;DR: This introductory article will focus on discussion of the essential roles of proteases in cell behavior and survival and death of all organisms, and the large collection of findings demonstrating their relevance in the control of multiple biological processes in all living organisms.

TL;DR: Conformation-dependent antibodies that recognize generic epitopes that are specifically associated with distinct aggregation states of many different amyloid-forming sequences indicate that there are at least two fundamentally distinct types of amyloidal oligomers: fibrillar and prefibrilar oligomers.

TL;DR: It is shown that polyphenols, including resveratrol and the synthetic polyphenol S17834, increase SIRT1 deacetylase activity, LKB1 phosphorylation at Ser428, and AMPK activity, which suggests that Sirt1 functions as a novel upstream regulator for L KB1/AMPK signaling and plays an essential role in the regulation of hepatocyte lipid metabolism.

TL;DR: Significantly, it is discovered that LATS1 inactivates YAP oncogenic function by suppressing its transcription regulation of cellular genes via sequestration of YAP in the cytoplasm after phosphorylation of Y AP.

TL;DR: The results suggest that LKB1 deacetylation is regulated by SIRT1 and that this in turn influences its intracellular localization, association with STRAD, kinase activity, and ability to activate AMPK.

TL;DR: This is the first study demonstrating a relationship between miR-221/222 expression and HER2/neu overexpression in primary breast tumors that are generally resistant to tamoxifen therapy, and provides the rationale for the application of altered expression of specific miRNAs as a predictive tamoxIFen-resistant breast cancer marker.

TL;DR: In vivo analyses demonstrated that p62 mutants lacking LC3 binding ability accumulated without entrapping into autophagosomes in the cytoplasm and subsequently formed ubiquitin-positive inclusion bodies as in autophagy-deficient cells, demonstrating that the intracellular level of p62 is tightly regulated by Autophagy through the direct interaction of LC3 with p62.

TL;DR: Physiologic double-strand break processes make use of the imprecision of NHEJ in generating antigen receptor diversity and Pathologically, the imp Recursion of N HEJ contributes to genome mutations that arise over time.

TL;DR: It is shown that CMA and macroautophagy are important pathways for WT ASYN degradation in neurons and underline the importance of CMA as degradation machinery in the nervous system.

TL;DR: The current knowledge on the functional principles of this molecular machine, including the ATPdriven chaperone cycle of Hsp90 and its regulation by co-chaperones and post-translational modifications are summarized.

TL;DR: A critical role is demonstrated for AKT-mediated induction of Runx2 in oxidative stress-induced VSMC calcification, which promotes a phenotypic switch of VSMC from contractile to osteogenic phenotype.

TL;DR: This review discusses how the organic osmolytes protect, the identity of o smolytes in Archaea, bacteria, yeast, plants, marine animals, and mammals, the mechanisms by which they are accumulated, and the signaling pathways involved.

TL;DR: It is demonstrated that TNFα-induced NF-κB activation is severely diminished in the absence of both c-IAP proteins, and TNF α-induced RIP1 ubiquitination is abrogated in the presence of c- IAPs.

TL;DR: Findings indicate thatmiR-221 and miR-222 play a significant role in the regulation of ER α expression at the protein level and could be potential targets for restoring ERα expression and responding to antiestrogen therapy in a subset of breast cancers.

TL;DR: FTLD-U/ALS pathogenesis may be linked mechanistically to deleterious perturbations of nuclear trafficking and solubility of TDP-43, as well as to mutants with defective nuclear localization or nuclear export signals.

TL;DR: By determining the kinetics of protein assembly following DNA damage, this study reveals the cooperation between PARP1 and the double strand break sensors MRE11 and NBS1 in the close vicinity of a DNA lesion, which may explain the sensitivity of cancer cells to PARP inhibitors.

TL;DR: In Arabidopsis, microRNA-mediated down-regulation is a general mechanism to regulate nonessential copper proteins and it is proposed that this mechanism allows plants to save copper for the most essential functions during limited copper supply.

TL;DR: It is shown that in yeast and mammalian mitochondria, superoxide production by paraquat occurs in the mitochondrial matrix, as inferred from manganese superoxide dismutase-sensitive mitochondrial DNA damage, as well as from superoxide assays in isolated mitochondaria, which were unaffected by exogenous superoxide Dismutase.

TL;DR: The use of mass spectrometric methods to identify the site and extent of protein carbonylation on a proteome-wide scale has expanded the view of how oxidative stress can regulate cellular processes.

TL;DR: A role for CXCR7/RDC1 in PCa metastasis and progression is demonstrated and potential targets for therapeutic intervention are suggested.

TL;DR: Osterix is regulated via both Runx2-dependent and -independent mechanisms, and that Osterix controls osteoblast differentiation, at least in part, by regulating the expression of genes not controlled by Runx 2.

TL;DR: The results suggests that APAP-induced liver injury involves JNK activation, due to increased reactive oxygen species generated by GSH-depleted mitochondria, and translocation of activated JNK to mitochondria where JNK induces mitochondrial permeability transition and inhibits mitochondria bioenergetics.

TL;DR: This review is focused on novel biological functions of SLRP with special emphasis on their protein cores, newly described genetic diseases, and signaling events in which SLRPs play key functions.