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Maria Jesus Almela

Researcher at GlaxoSmithKline

Publications -  17
Citations -  534

Maria Jesus Almela is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Plasmodium falciparum & Gametocyte. The author has an hindex of 8, co-authored 17 publications receiving 468 citations. Previous affiliations of Maria Jesus Almela include National University of Distance Education & Spanish National Research Council.

Papers
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Journal ArticleDOI

Activity of clinically relevant antimalarial drugs on Plasmodium falciparum mature gametocytes in an ATP bioluminescence “transmission blocking”assay

Joël Lelièvre, +6 more
- 13 Apr 2012 - 
TL;DR: An efficient method to produce and purify mature gametocytes in vitro and an assay to determine the activity of antimalarial drugs based on the intracellular ATP content of purified stage IV–Vgametocytes after 48 h of drug exposure in 96/384-well microplates are designed.
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Sordarins: In Vitro Activities of New Antifungal Derivatives against Pathogenic Yeasts, Pneumocystis carinii, and Filamentous Fungi

Esperanza Herreros, +5 more
- 01 Nov 1998 - 
TL;DR: It is concluded that some sordarin derivatives, such as GM 222712 and GM 237354, showed excellent in vitro activities against a wide range of pathogenic fungi, including Candida spp.
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A New Set of Chemical Starting Points with Plasmodium falciparum Transmission-Blocking Potential for Antimalarial Drug Discovery.

Maria Jesus Almela, +7 more
- 28 Aug 2015 - 
TL;DR: Screening results for the Tres Cantos Antimalarial Set (TCAMS) report the identification of 98 selective molecules with dual activity against gametocytes and asexual stages, and new chemical structures not connected to previously described antimalarials have been identified.
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Antifungal Activities and Cytotoxicity Studies of Six New Azasordarins

Esperanza Herreros, +4 more
- 01 Nov 2001 - 
TL;DR: In vitro selectivity of azasordarins showed significant activity against emerging fungal pathogens, which affect immunocompromised patients, such as Rhizopus arrhizus, Blastoschizomyces capitatus, and Geotrichum clavatum.
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Inhibitors of poliovirus uncoating efficiently block the early membrane permeabilization induced by virus particles.

Maria Jesus Almela, +2 more
- 01 May 1991 - 
TL;DR: The uncoating of poliovirus is required for the permeabilization of cell membranes to proteins, and it is concluded that the delivery to the cytoplasm of some molecules that coenter with virion particles does not take place if the un coating process is hindered.