Maria Korosteleva

TL;DR: Trinucleotide phosphoramidites that correspond to the codons of all 20 amino acids were synthesized in high yield in 5g scale and the synthons have been used for automated synthesis of oligonucleotides and corresponding libraries by a phosphite-triester approach.

TL;DR: A new method to produce a set of 20 high quality trinucleotide phosphoramidites on a 5–10 g scale each was developed and mutagenic oligonucleotides are synthesized employing mixtures of building blocks 7 as well as following the new synthetic protocol.

TL;DR: The experimental UV-spectra of trinucleotides show a good agreement with theoretical ones and were used for synthesis oftrinucleotide phosphoramidites - synthons for generation of DNA/peptide libraries.

TL;DR: Trinucleotide phosphoramidites that correspond to the codons of all 20 amino acids were synthesized in high yield in 5g scale and the synthons have been used for automated synthesis of oligonucleotides and corresponding libraries by a phosphite-triester approach.

TL;DR: The developed assay system allowed us to detect five patients, who are heterozygous for factor V Leiden among the 48 patients with deep venous thrombosis and pulmonary thromboembolism.