M
María Pascual
Researcher at University of Valencia
Publications - 71
Citations - 4586
María Pascual is an academic researcher from University of Valencia. The author has contributed to research in topics: Neuroinflammation & Brain damage. The author has an hindex of 34, co-authored 68 publications receiving 3988 citations. Previous affiliations of María Pascual include Polytechnic University of Valencia & Carlos III Health Institute.
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Intermittent ethanol exposure induces inflammatory brain damage and causes long-term behavioural alterations in adolescent rats.
TL;DR: The findings indicate that binge pattern exposure to ethanol during adolescence induces brain damage by inflammatory processes and causes long‐lasting neurobehavioural consequences, and administering indomethacin protects against ethanol‐induced brain damage and prevents detrimental ethanol effects on cognitive and motor processes.
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Repeated alcohol administration during adolescence causes changes in the mesolimbic dopaminergic and glutamatergic systems and promotes alcohol intake in the adult rat
TL;DR: The findings demonstrate the sensitivity of adolescent brain to ethanol effects on dopaminergic and glutamatergic neurotransmission, and suggest that abnormal plasticity in reward‐related processes and epigenetic mechanisms could contribute to the vulnerability of adolescents to alcohol addiction.
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Mechanisms involved in the neurotoxic, cognitive, and neurobehavioral effects of alcohol consumption during adolescence
Consuelo Guerri,María Pascual +1 more
TL;DR: The potential mechanisms by which ethanol impacts brain development and lead to brain impairments and cognitive and behavioral dysfunctions are reviewed as well as the neurobiological and neurochemical processes underlying the adolescent-specific vulnerability to drug addiction are reviewed.
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Critical Role of TLR4 Response in the Activation of Microglia Induced by Ethanol
TL;DR: It is demonstrated that ethanol activates microglía and stimulates NF-κB, MAPKs, and MyD88-independent (IFN regulatory factor-3, IFN-β) pathways to trigger the production of inflammatory mediators, causing neuronal death.
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Chronic Ethanol Treatment Enhances Inflammatory Mediators and Cell Death in the Brain and in Astrocytes
TL;DR: Inflammatory processes and cytokine expression have been implicated in the pathogenesis of several neurodegenerative disorders and chronic ethanol intake induces brain damage.