Maria Salvato

TL;DR: This finding indicates that the GP 260 mutation is necessary but not sufficient for a CTL- P+ phenotype and that the reversion to CTL+ P- is likely either due to secondary mutations in other regions of the viral genome or to quasispecies within the revertant population that make significant contributions to the phenotype.

TL;DR: The completed sequence of LCMV reveals a formerly unknown gene (Z) on the L genomic segment, which is encoded in the positive or message-sense of the viral genomic RNA, whereas the adjacent gene (L) is in the genome-complementary, or negative sense.

TL;DR: CTL vaccines, to achieve optimal effectiveness, should not simply include virus sequences which will yield a CTL response; the immunizing sequences should also be selected to ensure that the fine specificities of the induced CTL are such that they maximize the chance of recognizing serotypically diverse strains.

TL;DR: The availability of the complete S RNA sequence for LCMV ARM and ARM Clone 13 variant allows a detailed comparison with THE AUTHORS (V. Romanowski et al. 3, 110-114), the only otherLCMV S RNA so far sequenced.

TL;DR: The complete RNA sequence of the L protein gene of lymphocytic choriomeningitis virus (LCMV) is presented, showing that the viral genes on the L strand are critical elements controlling virus replication and the pattern of LCMV infection.