Showing papers by "María Teresa Camacho Olmedo published in 2019"
TL;DR: The data indicate that the bacterial diets of C. elegans provide precisely tailored amounts of iron to support proper development, and suggests that low bacterial iron results in high bacterial ROS and vice versa, which causes oxidative stress in C. elegans that subsequently impairs mitochondrial function and delays development.
32 citations
TL;DR: Assessment of how the calibration of a Land Use Cover Change (LUCC) model differs according to variation of the thematic resolution of input Land Use Land Cover (LULC) maps and a proposal of criteria to follow to aid modellers and researchers in the selection of the proper thematicresolution for their analyses is proposed.
18 citations
TL;DR: This paper aims to investigate the effect that the Minimum Mapping Unit (MMU) and Minimum Mapped Width (MMW) of input vector maps have on a specific modelling application and proves the influence of these components of the scale on the simulations produced by the models.
15 citations
TL;DR: It is shown that the purine biosynthesis network is functionally conserved in Caenorhabditis elegans and adsl-1 (the gene encoding ADSL in C. elegans) is required for developmental timing, germline stem cell maintenance and muscle integrity, and evidence that germline maintenance is linked specifically to ADSL activity in the recycling pathway is presented.
Abstract: Purine homeostasis is ensured through a metabolic network widely conserved from prokaryotes to humans. Purines can either be synthesized de novo, reused, or produced by interconversion of extant metabolites using the so-called recycling pathway. Although thoroughly characterized in microorganisms, such as yeast or bacteria, little is known about regulation of the purine biosynthesis network in metazoans. In humans, several diseases are linked to purine metabolism through as yet poorly understood etiologies. Particularly, the deficiency in adenylosuccinate lyase (ADSL)-an enzyme involved both in the purine de novo and recycling pathways-causes severe muscular and neuronal symptoms. In order to address the mechanisms underlying this deficiency, we established Caenorhabditis elegans as a metazoan model organism to study purine metabolism, while focusing on ADSL. We show that the purine biosynthesis network is functionally conserved in C. elegans Moreover, adsl-1 (the gene encoding ADSL in C. elegans) is required for developmental timing, germline stem cell maintenance and muscle integrity. Importantly, these traits are not affected when solely the de novo pathway is abolished, and we present evidence that germline maintenance is linked specifically to ADSL activity in the recycling pathway. Hence, our results allow developmental and tissue specific phenotypes to be ascribed to separable steps of the purine metabolic network in an animal model.
13 citations
01 Jan 2019
TL;DR: This chapter aims to provide an overview of the concepts, sources and tools to manage the uncertainty in geospatial analysis, and addresses this topic from the Land Use Cover Change Modelling perspective.
Abstract: All data and geospatial analyses come with uncertainty. Although its importance has been widely recognized, uncertainty issues are still not correctly addressed in most of the current geospatial research. This chapter aims to provide an overview of the concepts, sources and tools to manage the uncertainty in geospatial analysis. To this end, we intend to increase the awareness about the importance of uncertainty for all geospatial data and analyses. Due to time and chapter length considerations, we address this topic from the Land Use Cover Change Modelling perspective.
6 citations