M
Maria-Teresa Piccoli
Researcher at Hannover Medical School
Publications - 7
Citations - 1723
Maria-Teresa Piccoli is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Cardiac fibrosis & Heart failure. The author has an hindex of 7, co-authored 7 publications receiving 1209 citations. Previous affiliations of Maria-Teresa Piccoli include National Institutes of Health.
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Non-coding RNAs in Development and Disease: Background, Mechanisms, and Therapeutic Approaches
TL;DR: This review guides the reader through important aspects of non-coding RNA biology, including their biogenesis, mode of actions, physiological function, as well as their role in the disease context (such as in cancer or the cardiovascular system).
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Inhibition of the Cardiac Fibroblast–Enriched lncRNA Meg3 Prevents Cardiac Fibrosis and Diastolic Dysfunction
Maria-Teresa Piccoli,Shashi Kumar Gupta,Janika Viereck,Ariana Foinquinos,Sabine Samolovac,Freya Luise Kramer,Ankita Garg,Janet Remke,Karina Zimmer,Sandor Batkai,Thomas Thum +10 more
TL;DR: A critical role is uncovered for Meg3 in the regulation of MMP-2 production by CFs in vitro and in vivo, identifying a new player in the development of cardiac fibrosis and potential new target for the prevention of cardiac remodeling.
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miR-21 promotes fibrosis in an acute cardiac allograft transplantation model
Shashi Kumar Gupta,Ryo Itagaki,Xiang Zheng,Sandor Batkai,Sabrina Thum,Fareed Ahmad,Lucas Van Aelst,Amit Sharma,Maria-Teresa Piccoli,Florian Weinberger,Jan Fiedler,Michael Heuser,Stephane Heymans,Christine S. Falk,Reinhold Förster,Sonja Schrepfer,Thomas Thum,Thomas Thum +17 more
TL;DR: In vivo inhibition of miR-21 is a novel strategy to target fibrosis development in cardiac allografts and patients with cardiac rejection after heart transplantation showed increased cardiac miR -21 levels.
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Noncoding RNAs as regulators of cardiomyocyte proliferation and death.
TL;DR: This review summarizes recent evidences on noncoding RNAs regulating proliferation and death of cardiomyocytes representing a future therapeutic for the treatment of heart diseases.
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Non-coding RNAs as modulators of the cardiac fibroblast phenotype
TL;DR: Recent evidences on non-Coding RNAs, including microRNAs and long non-codingRNAs that modulate the phenotype of cardiac fibroblasts are summarized and may serve in the future as targets for novel therapeutic strategies against cardiac fibrosis.