Julia Beermann

TL;DR: This review guides the reader through important aspects of non-coding RNA biology, including their biogenesis, mode of actions, physiological function, as well as their role in the disease context (such as in cancer or the cardiovascular system).

TL;DR: The authors' results identify a novel miRNA-cross-talk involving miR-30a-3p andmiR-212, which led to suppression of important endothelial genes such as GAB1 and SIRT1 finally culminating in impaired endothelial function; and microRNAs may have different biological roles despite having the same seed sequence.

TL;DR: This work examined the prognostic value of a specific candidate miRNA in a large cohort of patients with chronic heart failure enrolled in a multicentre clinical trial.

TL;DR: It is evidenced that the specific mitochondrial long noncoding RNAs uc004cov.4 and uc022bqu.1 were upregulated in patients with HOCM and they were also able to identify HocM and could be developed as useful clinical biomarkers in the future.

TL;DR: This study demonstrates the applicability of an innovative shRNA library approach to identify long non-coding RNA functions in a massive parallel approach and suggests Ntep to serve as an important regulator of fibroblast proliferation and function.