M
Marianna Alunni-Fabbroni
Researcher at University of Rochester Medical Center
Publications - 5
Citations - 530
Marianna Alunni-Fabbroni is an academic researcher from University of Rochester Medical Center. The author has contributed to research in topics: Cell cycle & Cyclin-dependent kinase. The author has an hindex of 5, co-authored 5 publications receiving 504 citations.
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Journal ArticleDOI
Na+/H+ exchanger-dependent intracellular alkalinization is an early event in malignant transformation and plays an essential role in the development of subsequent transformation-associated phenotypes
Stephan J. Reshkin,Antonia Bellizzi,Sandra Caldeira,Valentina Albarani,Ilaria Malanchi,Manuela Poignee,Marianna Alunni-Fabbroni,Valeria Casavola,Massimo Tommasino +8 more
TL;DR: The data confirm that activation of the NHE‐1 and resulting cellular alkalinization is a key mechanism in oncogenic transformation and is necessary for the development and maintenance of the transformed phenotype.
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Separation of C/EBPα-mediated proliferation arrest and differentiation pathways
Christine Müller,Marianna Alunni-Fabbroni,Elisabeth Kowenz-Leutz,Xianming Mo,Massimo Tommasino,Achim Leutz +5 more
TL;DR: C/EBPalpha-mediated proliferation arrest and differentiation pathways can be separated by the E7 oncoprotein of the "high-risk" human papilloma virus without compromising the transactivation activity of C/ EBPalpha or its ability to participate in differentiation.
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Overriding of cyclin-dependent kinase inhibitors by high and low risk human papillomavirus types: evidence for an in vivo role in cervical lesions.
Ingeborg Zehbe,Andreas Rätsch,Marianna Alunni-Fabbroni,Annett Burzlaff,Evi Bakos,Matthias Dürst,Erik Wilander,Massimo Tommasino +7 more
TL;DR: It is concluded that the CKI neutralization by HPVs is likely to be required for viral DNA replication rather than for malignant transformation of the host cell.
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Identification of a novel activity of human papillomavirus type 16 E6 protein in deregulating the G1/S transition.
Ilaria Malanchi,Sandra Caldeira,Maja Krützfeldt,Marianna Giarrè,Marianna Alunni-Fabbroni,Massimo Tommasino +5 more
TL;DR: A novel biological function of HPV E6 is described and it is shown that the S phase entry, required for viral DNA replication, is not exclusively controlled by E7, but that E6 also is involved in this event.
Journal ArticleDOI
Induction of S phase and apoptosis by the human papillomavirus type 16 E7 protein are separable events in immortalized rodent fibroblasts.
Marianna Alunni-Fabbroni,T Littlewood,L Deleu,Sandra Caldeira,Marianna Giarrè,M Dell' Orco,Massimo Tommasino +6 more
TL;DR: It is demonstrated that the ability to induce apoptosis is a common property of E7s belonging to both benign and malignant HPV types, and that these two E7-mediated cellular events, apoptosis and S phase entry, can be separated in immortalized rodent fibroblasts.