M
Marianna Leonzino
Researcher at Yale University
Publications - 6
Citations - 531
Marianna Leonzino is an academic researcher from Yale University. The author has contributed to research in topics: Organelle & Lipid Transport. The author has an hindex of 4, co-authored 6 publications receiving 294 citations. Previous affiliations of Marianna Leonzino include Howard Hughes Medical Institute.
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Journal ArticleDOI
VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites.
Nikit Kumar,Marianna Leonzino,William Hancock-Cerutti,Florian A. Horenkamp,PeiQi Li,Joshua A. Lees,Heather E. Wheeler,Karin M. Reinisch,Pietro De Camilli +8 more
TL;DR: It is shown that the N-terminal portion of VPS13 is tubular, with a hydrophobic cavity that can solubilize and transport glycerolipids between membranes, implicating defects in membrane lipid homeostasis in neurological disorders resulting from their mutations.
Journal ArticleDOI
VPS13D bridges the ER to mitochondria and peroxisomes via Miro.
Andrés Guillén-Samander,Marianna Leonzino,Michael G. Hanna,Ni Tang,Hongying Shen,Pietro De Camilli +5 more
TL;DR: In this paper, the outer mitochondrial membrane GTPase Gem1 was linked to mitochondrial dynamics but not to lipid transport in yeast and higher eukaryotes, with potential implications for Parkinson's disease pathogenesis.
Journal ArticleDOI
Insights into VPS13 properties and function reveal a new mechanism of eukaryotic lipid transport.
TL;DR: In this article, a rod-like protein bridge with a hydrophobic groove through which lipids can slide is proposed for bulk transport of bilayer lipids to promote membrane growth.
Journal ArticleDOI
Role of VPS13, a protein with similarity to ATG2, in physiology and disease
TL;DR: Genetic, functional and structural studies have revealed that VPS13 acts at contact sites between intracellular organelles to transport lipids by a novel mechanism: direct transfer between bilayers via a hydrophobic channel that spans its entire rod-like N-terminal half.
Posted ContentDOI
VPS13D bridges the ER to Miro containing membranes
Andrés Guillén-Samander,Marianna Leonzino,Michael G. Hanna,Ni Tang,Hongying Shen,Pietro De Camilli +5 more
TL;DR: Guillen-Samander et al. as discussed by the authors showed that Miro, including its peroxisome-enriched splice variant, recruits the lipid transport protein VPS13D, which in turn binds the ER in a VAP-dependent way and thus could provide a lipid conduit between the ER and mitochondria.