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Berrak Ugur
Researcher at Baylor College of Medicine
Publications - 11
Citations - 567
Berrak Ugur is an academic researcher from Baylor College of Medicine. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 6, co-authored 7 publications receiving 346 citations. Previous affiliations of Berrak Ugur include Yale University.
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Drosophila tools and assays for the study of human diseases.
TL;DR: Assays that have been developed in flies to study the function of specific genes in the central nervous system, heart, liver and kidney are discussed, and examples of the use of these assays to address questions related to human diseases are provided.
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Large-scale identification of chemically induced mutations in Drosophila melanogaster
Nele A Haelterman,Lichun Jiang,Yumei Li,Vafa Bayat,Hector Sandoval,Berrak Ugur,Kai Li Tan,Ke Zhang,Danqing Bei,Bo Xiong,Wu Lin Charng,Theodore Busby,Adeel Jawaid,Gabriela David,Manish Jaiswal,Koen J. T. Venken,Shinya Yamamoto,Shinya Yamamoto,Rui Chen,Hugo J. Bellen +19 more
TL;DR: This work sequenced 394 mutant strains for essential genes on the Drosophila X chromosome and showed that 274 mutations are causative, using small 80-kb duplications that rescue lethality, demonstrating that combining rough mapping with WGS dramatically expands the toolkit necessary for assigning function to genes.
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Role of VPS13, a protein with similarity to ATG2, in physiology and disease
TL;DR: Genetic, functional and structural studies have revealed that VPS13 acts at contact sites between intracellular organelles to transport lipids by a novel mechanism: direct transfer between bilayers via a hydrophobic channel that spans its entire rod-like N-terminal half.
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The Krebs Cycle Enzyme Isocitrate Dehydrogenase 3A Couples Mitochondrial Metabolism to Synaptic Transmission.
Berrak Ugur,Huan Bao,Michal Stawarski,Lita Duraine,Zhongyuan Zuo,Yong Qi Lin,G. Gregory Neely,Gregory T. Macleod,Edwin R. Chapman,Hugo J. Bellen +9 more
TL;DR: A role is uncovered for isocitrate dehydrogenase 3a (idh3a), a Krebs cycle enzyme, in neurotransmission, causing defects in synaptic transmission similar to the loss of syt1, and αKG, a metabolite proposed as a treatment for aging and neurodegenerative disorders, is provided.
Journal ArticleDOI
cindr, the Drosophila Homolog of the CD2AP Alzheimer's Disease Risk Gene, Is Required for Synaptic Transmission and Proteostasis.
Shamsideen A. Ojelade,Shamsideen A. Ojelade,Tom V. Lee,Tom V. Lee,Nikolaos Giagtzoglou,Nikolaos Giagtzoglou,Lei Yu,Berrak Ugur,Yarong Li,Yarong Li,Lita Duraine,Zhongyuan Zuo,Vlad Petyuk,Philip L. De Jager,Philip L. De Jager,David A. Bennett,Benjamin R. Arenkiel,Hugo J. Bellen,Joshua M. Shulman +18 more
TL;DR: The results reveal CD2AP neuronal requirements with relevance to AD susceptibility, including for proteostasis, calcium handling, and synaptic structure and function.