M
Marie-Christine W. Gast
Researcher at Netherlands Cancer Institute
Publications - 16
Citations - 690
Marie-Christine W. Gast is an academic researcher from Netherlands Cancer Institute. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 12, co-authored 16 publications receiving 667 citations. Previous affiliations of Marie-Christine W. Gast include Utrecht University.
Papers
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Journal ArticleDOI
Clinical proteomics: searching for better tumour markers with SELDI-TOF mass spectrometry
Judith Y. M. N. Engwegen,Marie-Christine W. Gast,Jan H.M. Schellens,Jan H.M. Schellens,Jos H. Beijnen,Jos H. Beijnen +5 more
TL;DR: Current proteomic technologies are particularly suitable for protein profiling in the search for new biomarkers, but reproducibility and validation of these biomarkers should be addressed carefully, as should their origin and identity.
Journal ArticleDOI
Clinical proteomics in breast cancer: a review
TL;DR: MALDI- and SELDI-TOF MS protein profiling studies could eventually fulfil the great promise that protein biomarkers have for improving cancer patient outcome, provided that these studies are performed with adequate statistical power and analytical rigour.
Journal ArticleDOI
Searching for early breast cancer biomarkers by serum protein profiling of pre-diagnostic serum; a nested case-control study
Annemieke W. J. Opstal-van Winden,Annemieke W. J. Opstal-van Winden,Esmeralda Krop,Monica Kåredal,Marie-Christine W. Gast,Christian H. Lindh,Marina C. Jeppsson,Bo A. G. Jönsson,Diederick E. Grobbee,Petra H.M. Peeters,Jos H. Beijnen,Jos H. Beijnen,Carla H. van Gils,Roel Vermeulen +13 more
TL;DR: It is shown that serum protein profiles are already altered up to three years before breast cancer detection.
Journal ArticleDOI
Validation of previously identified serum biomarkers for breast cancer with SELDI-TOF MS: a case control study
Annemieke W J van Winden,Annemieke W J van Winden,Marie-Christine W. Gast,Jos H. Beijnen,Jos H. Beijnen,Emiel J. Th. Rutgers,Diederick E. Grobbee,Petra H.M. Peeters,Carla H. van Gils +8 more
TL;DR: This study validate three proteins previously reported to be discriminative between breast cancer cases and healthy controls with surface-enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS).
Journal ArticleDOI
Comparison of normalisation methods for surface-enhanced laser desorption and ionisation (SELDI) time-of-flight (TOF) mass spectrometry data
Wouter Meuleman,Wouter Meuleman,Judith Y. M. N. Engwegen,Marie-Christine W. Gast,Jos H. Beijnen,Marcel J. T. Reinders,Lodewyk F. A. Wessels,Lodewyk F. A. Wessels +7 more
TL;DR: This paper describes the first systematic comparison of a wide range of normalisation methods, using two objectives that should be met by a good method: minimisation of inter-spectra variance and maximisation of signal with respect to class separation.