M
Marie-Odile Benoit-Biancamano
Researcher at Université de Montréal
Publications - 55
Citations - 807
Marie-Odile Benoit-Biancamano is an academic researcher from Université de Montréal. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 14, co-authored 40 publications receiving 685 citations. Previous affiliations of Marie-Odile Benoit-Biancamano include Laval University & Charles River Laboratories.
Papers
More filters
Journal ArticleDOI
The Impact of UGT1A8, UGT1A9, and UGT2B7 Genetic Polymorphisms on the Pharmacokinetic Profile of Mycophenolic Acid After a Single Oral Dose in Healthy Volunteers
Éric Lévesque,Robert Delage,Marie-Odile Benoit-Biancamano,Patrick Caron,Olivier Bernard,Félix Couture,Chantal Guillemette +6 more
TL;DR: After a single oral dose of MMF in healthy volunteers, specific UGT genotypes significantly alter MPA PKs and this clearly warrants additional studies with complete and detailed genetic profiling of UGT 1A8, UGT1A9, and UGT2B7 genes.
Journal ArticleDOI
A pharmacogenetics study of the human glucuronosyltransferase UGT1A4.
Marie-Odile Benoit-Biancamano,Jean-Philippe Adam,Olivier Bernard,Michael H. Court,Marie-Hélène Leblanc,Patrick Caron,Chantal Guillemette +6 more
TL;DR: Investigation of genetic mechanisms that might contribute to interindividual variation in UGT1A4 expression and activity identified a large number of genetic variations, including 13 intronic, 39 promoter, as well as 14 exonic polymorphisms, with 10 that lead to amino-acid changes.
Journal ArticleDOI
Pharmacokinetics of mycophenolate mofetil and its glucuronide metabolites in healthy volunteers.
TL;DR: It is demonstrated that MPA disposition is a multigenic process, and that additional studies are required to ascertain the relationship between UGT, ABCC2 genotypes and MPA pharmacokinetics in transplant recipients.
Journal ArticleDOI
Pre- and Postnatal Development of the Eye: A Species Comparison.
Steven Van Cruchten,Vanessa Vrolyk,Marie-France Perron Lepage,Marie Baudon,Hélène Voute,Sabine Schoofs,Julius Haruna,Marie-Odile Benoit-Biancamano,Benoît Ruot,Karel Allegaert,Karel Allegaert +10 more
TL;DR: All commonly used nonclinical species appear to be relatively good models for human eye development, although some practical constraints such as size may be a limiting factor.
Journal ArticleDOI
Deferiprone glucuronidation by human tissues and recombinant UDP glucuronosyltransferase 1A6: an in vitro investigation of genetic and splice variants.
Marie-Odile Benoit-Biancamano,John Connelly,Lyne Villeneuve,Patrick Caron,Chantal Guillemette +4 more
TL;DR: Deferiprone glucuronidation seems to depend almost totally on UGT1A6, especially in the liver, and genetic variations and differences in the expression of splice variants represent a potential source of variation in deferiprone metabolism.