M
Marilene M. Canto-Cavalheiro
Researcher at Oswaldo Cruz Foundation
Publications - 36
Citations - 1047
Marilene M. Canto-Cavalheiro is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Visceral leishmaniasis & Mesoionic. The author has an hindex of 19, co-authored 36 publications receiving 900 citations. Previous affiliations of Marilene M. Canto-Cavalheiro include Federal Fluminense University.
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Reactive oxygen species production and mitochondrial dysfunction contribute to quercetin induced death in Leishmania amazonensis.
TL;DR: The results demonstrate that quercetin eventually exerts its antileishmanial effect on L. amazonensis promastigotes due to the generation of ROS and disrupted parasite mitochondrial function.
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Evaluation of the direct agglutination test and the rK39 dipstick test for the sero-diagnosis of visceral leishmaniasis
TL;DR: The DAT is the most suitable test for the sero-diagnosis of VL under field conditions because the reagents used for DAT do not require cold storage, whereas the buffer of the rK39 must be stored at 4oC.
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Reactive Oxygen Species Production by Quercetin Causes the Death of Leishmania amazonensis Intracellular Amastigotes
TL;DR: Results suggest that ROS production plays a role in the mechanism of action of 1 in the control of intracellular amastigotes of L. amazonensis.
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LQB-118, an orally active pterocarpanquinone, induces selective oxidative stress and apoptosis in Leishmania amazonensis
Grazielle Alves Ribeiro,Edézio Ferreira Cunha-Júnior,Roberta Olmo Pinheiro,Silvia Amaral Gonçalves Da-Silva,Marilene M. Canto-Cavalheiro,Alcides J. M. da Silva,Paulo R. R. Costa,Chaquip D. Netto,Rossana C. N. Melo,Elmo E. Almeida-Amaral,Eduardo Caio Torres-Santos +10 more
TL;DR: The results suggest that LQB-118 selectively induces ROS-triggered and mitochondria-dependent apoptosis in this parasite.
Journal ArticleDOI
Effect of Apigenin on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction.
Fernanda Fonseca-Silva,Marilene M. Canto-Cavalheiro,Rubem F. S. Menna-Barreto,Elmo E. Almeida-Amaral +3 more
TL;DR: The results demonstrate the leishmanicidal effect of 1 and suggest the involvement of ROS leading to mitochondrial collapse as part of the mechanism of action.