https://caltcm.memberclicks.net/assets/documents/acc_aha_chf_2013_guidelines.pdf

2013 ACCF/AHA Guideline for the Management of Heart Failure: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines

http://science.sciencemag.org/content/sci/201/4359/899.2.full.pdf

Phenomenology of perception.

CA : A Cancer Journal for Clinicians

Summary Background Since December, 2019, Wuhan, China, has experienced an outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Epidemiological and clinical characteristics of patients with COVID-19 have been reported but risk factors for mortality and a detailed clinical course of illness, including viral shedding, have not been well described. Methods In this retrospective, multicentre cohort study, we included all adult inpatients (≥18 years old) with laboratory-confirmed COVID-19 from Jinyintan Hospital and Wuhan Pulmonary Hospital (Wuhan, China) who had been discharged or had died by Jan 31, 2020. Demographic, clinical, treatment, and laboratory data, including serial samples for viral RNA detection, were extracted from electronic medical records and compared between survivors and non-survivors. We used univariable and multivariable logistic regression methods to explore the risk factors associated with in-hospital death. Findings 191 patients (135 from Jinyintan Hospital and 56 from Wuhan Pulmonary Hospital) were included in this study, of whom 137 were discharged and 54 died in hospital. 91 (48%) patients had a comorbidity, with hypertension being the most common (58 [30%] patients), followed by diabetes (36 [19%] patients) and coronary heart disease (15 [8%] patients). Multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1·10, 95% CI 1·03–1·17, per year increase; p=0·0043), higher Sequential Organ Failure Assessment (SOFA) score (5·65, 2·61–12·23; p Interpretation The potential risk factors of older age, high SOFA score, and d-dimer greater than 1 μg/mL could help clinicians to identify patients with poor prognosis at an early stage. Prolonged viral shedding provides the rationale for a strategy of isolation of infected patients and optimal antiviral interventions in the future. Funding Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences; National Science Grant for Distinguished Young Scholars; National Key Research and Development Program of China; The Beijing Science and Technology Project; and Major Projects of National Science and Technology on New Drug Creation and Development.

Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study

### A. Overview

Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are important signaling molecules that mediate diverse biological effects via cell-surface receptors termed purine receptors. In this review particular emphasis is placed on the discrepancy between the

/pdf/receptors-for-purines-and-pyrimidines-56f78tnpew.pdf

Receptors for Purines and Pyrimidines

Systems Biological Identification of an Age-related Predictor of Functional Recovery Potential in Advanced Heart Failure

Cardiac Retransplantation: Third Time’s the Charm?

Purpose One major function of the 26S proteasome is antigen processing for HLA class I presentation. Following proteasome inhibition with bortezomib (Bzb), one would expect down regulation of class I expression. We explored the differential effect on donor specific and third-party antibodies in Bzb-treated OHT patients. We postulated that compared to class II responses, Bzb is more effective in preventing de novo antibody production to class I alloantigens. Methods and Materials Pearson correlations among Ab per and across patients were performed for patients receiving Bzb desensitization/AMR therapy from August 2010 to January 2012. Hierarchical clustering was used to find antibody groups of similar response. Treatment consisted of plasmapheresis then Bzb (0.7-1mg/m² IV) on days 1, 4, 7, 10 then a 3-day course of plasmapheresis beginning day 13. Anti-HLA antibody mean fluorescence intensity (MFI) was determined via single antigen Luminex® assay. Results Evaluation of the antibody response patterns to Bzb was done on 9 patients. Out of these, 4 patients shared common antibodies, tested multiple times before and after transplantation. Antibody levels are depicted as a heatmap for the intersection of antibody sets. We found that compared to HLA class I locus A and B, HLA class II antibodies demonstrated a significantly decreased response to Bzb. [ figure 1 ] Conclusions We have identified clusters of antibodies with differing degrees of response to Bzb therapy that could be indicative of a class-specific effect. Class I antibodies show a preferential response to bortezomib, while Class II (specifically HLA-DQ) appeared to respond poorly. Our findings suggests that individualized, HLA-specific therapies targeting specific antibody clusters merits further study.

Reduced HLA Class II Antibody Response to Proteasome Inhibition

Book Review Heart Transplantation By James K. Kirklin, James B. Young, and David C. McGiffin. 883 pp., illustrated. New York, Churchill Livingstone, 2002. $229. 0-443-07655-3

Mario C. Deng

Papers

Systems Biological Identification of an Age-related Predictor of Functional Recovery Potential in Advanced Heart Failure

Cardiac Retransplantation: Third Time’s the Charm?

Reduced HLA Class II Antibody Response to Proteasome Inhibition

Book Review Heart Transplantation By James K. Kirklin, James B. Young, and David C. McGiffin. 883 pp., illustrated. New York, Churchill Livingstone, 2002. $229. 0-443-07655-3

Survival in adults undergoing primary heart transplant after fontan palliation