M
Mario H. Skiadopoulos
Researcher at United States Department of Health and Human Services
Publications - 7
Citations - 172
Mario H. Skiadopoulos is an academic researcher from United States Department of Health and Human Services. The author has contributed to research in topics: Anthrax vaccines & Bacillus anthracis. The author has an hindex of 6, co-authored 7 publications receiving 146 citations.
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Journal ArticleDOI
Evaluation of immunogenicity and efficacy of anthrax vaccine adsorbed for postexposure prophylaxis.
Boris Ionin,Robert J. Hopkins,Brett Pleune,Gloria S. Sivko,Frances M. Reid,Kristin H. Clement,Thomas L. Rudge,Gregory V. Stark,Alison Innes,Suha Sari,Tina Guina,Cris Howard,Jeffrey G. Smith,M. Lisa Swoboda,Ekaterina Vert-Wong,Virginia Johnson,Gary S. Nabors,Mario H. Skiadopoulos +17 more
TL;DR: The animal data provide initial information on protective antibody levels for anthrax, as well as support previous findings regarding the ability of AVA to provide added protection to B. anthracis-infected animals compared to antimicrobial treatment alone.
Journal ArticleDOI
Evaluation of Intravenous Anthrax Immune Globulin for Treatment of Inhalation Anthrax
Nutan Mytle,Robert J. Hopkins,Nina V. Malkevich,Subhendu Basu,Gabriel T. Meister,Daniel C. Sanford,Jason E. Comer,Kristopher E. Van Zandt,Mohamed Al-Ibrahim,William Kramer,Cris Howard,Nancy F. Daczkowski,Ajoy C. Chakrabarti,Boris Ionin,Gary S. Nabors,Mario H. Skiadopoulos +15 more
TL;DR: In a time-based treatment study, AIGIV protected 89 to 100% of animals when administered 12 h postexposure; however, a lower survival rate was observed when animals were treated 24 h post exposure, underscoring the need for early intervention.
Journal ArticleDOI
Pathology and Pathophysiology of Inhalational Anthrax in a Guinea Pig Model
Vladimir Savransky,Daniel C. Sanford,Emily S Syar,Jamie L. Austin,Kevin P. Tordoff,Michael S. Anderson,Gregory V. Stark,Roy E. Barnewall,Crystal M. Briscoe,Laurence Lemiale-Biérinx,Sukjoon Park,Boris Ionin,Mario H. Skiadopoulos +12 more
TL;DR: It is demonstrated that the course of inhalational anthrax disease and the resulting pathology in guinea pigs are similar to those seen in rabbits and NHPs, as well as in humans.
Journal ArticleDOI
Effect of Anthrax Immune Globulin on Response to BioThrax (Anthrax Vaccine Adsorbed) in New Zealand White Rabbits
Nina V. Malkevich,Subhendu Basu,Thomas L. Rudge,Kristin H. Clement,Ajoy C. Chakrabarti,Ronald T. Aimes,Gary S. Nabors,Mario H. Skiadopoulos,Boris Ionin +8 more
TL;DR: While pharmacokinetics of AIGIV were not altered by vaccination, the vaccine-induced immune response was abrogated in AigIV-treated animals and BioThrax (anthrax vaccine adsorbed) in rabbits.
Journal ArticleDOI
Efficacy and Safety of AVP-21D9, an Anthrax Monoclonal Antibody, in Animal Models and Humans
Nina V. Malkevich,Robert J. Hopkins,Edward Bernton,Gabriel T. Meister,Eric M. Vela,George Atiee,Virginia Johnson,Gary S. Nabors,Ronald T. Aimes,Boris Ionin,Mario H. Skiadopoulos +10 more
TL;DR: An anthrax antitoxin, AVP-21D9, also known as Thravixa (fully human anthrax monoclonal antibody), is being developed as a therapeutic agent against anthrax toxemia and resulted in survival in therapeutic efficacy animal models and in healthy human volunteers.