M
Mário Sousa
Researcher at University of Porto
Publications - 294
Citations - 8193
Mário Sousa is an academic researcher from University of Porto. The author has contributed to research in topics: Sperm & Spermatogenesis. The author has an hindex of 44, co-authored 270 publications receiving 7164 citations. Previous affiliations of Mário Sousa include French Institute of Health and Medical Research & University of Granada.
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Journal ArticleDOI
Abnormal methylation of imprinted genes in human sperm is associated with oligozoospermia.
C. J. Marques,Paula María de Carvalho Pinto Costa,B. Vaz,Filipa Carvalho,Susana Fernandes,Alberto Barros,Mário Sousa +6 more
TL;DR: Findings could contribute to an explanation of the cause of Silver-Russell syndrome in children born with H19 hypomethylation after assisted reproductive technologies (ART), and unmethylation of the CTCF-binding site could lead to inactivation of the paternal IGF2 gene, and be linked to decreased embryo quality and birth weight.
Journal ArticleDOI
Genomic imprinting in disruptive spermatogenesis.
TL;DR: The data suggest an association between abnormal genomic imprinting and hypospermatogenesis, and that spermatozoa from oligozoospermic patients carry a raised risk of transmitting imprinting errors.
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Human oocyte activation after intracytoplasmic sperm injection
TL;DR: In this paper, the authors used confocal laser scanning microscopy to examine the changes in the concentration of intracellular free calcium (Ca2+]i) in human oocytes after intracytoplasmic sperm injection (ICSI).
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High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia.
S. Fernandes,K. Huellen,João Gonçalves,H. Dukal,J. Zeisler,E. Rajpert De Meyts,Niels E. Skakkebæk,Barbara Habermann,Walter Krause,Mário Sousa,Alberto Barros,Peter H. Vogt +11 more
TL;DR: It is concluded that the deletion of the DAZ1/DAZ2 gene doublet in five out of the authors' 63 oligozoospermic patients (8%) is responsible for the patients' reduced sperm numbers, most likely caused by intrachromosomal recombination events between two long repetitive sequence blocks (AZFc-Rep1) flanking theDAZ gene structures.
Journal ArticleDOI
High deletion frequency of the complete AZFa sequence in men with Sertoli-cell-only syndrome.
Christine Kamp,K. Huellen,Susana Fernandes,Mário Sousa,Peter N. Schlegel,Anna Mielnik,S. Kleiman,H. Yavetz,Walter Krause,Wolfgang Küpker,R. Johannisson,W. Schulze,Wolfgang Weidner,Alberto Barros,Peter H. Vogt +14 more
TL;DR: It is shown that similar AZFa deletions occur with a frequency of 9% in the SCO patient group, which may provide a valuable prognostic tool for infertility clinics performing testicular sperm extraction, as it would enable the exclusion of AZFa patients with a complete SCO syndrome.