M
Maritza Chirivella
Researcher at Centers for Disease Control and Prevention
Publications - 3
Citations - 326
Maritza Chirivella is an academic researcher from Centers for Disease Control and Prevention. The author has contributed to research in topics: Dengue virus & Dengue fever. The author has an hindex of 3, co-authored 3 publications receiving 307 citations.
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Journal ArticleDOI
Selection-driven evolution of emergent dengue virus.
Shannon N. Bennett,Edward C. Holmes,Maritza Chirivella,Dania M. Rodriguez,Manuela Beltran,Vance Vorndam,Duane J. Gubler,W. Owen McMillan +7 more
TL;DR: This study demonstrates viral genetic turnover within a focal population and the potential importance of adaptive evolution in viral epidemic expansion and the role of viral molecular evolution in emergent disease dynamics.
Journal ArticleDOI
Molecular evolution of dengue 2 virus in Puerto Rico: positive selection in the viral envelope accompanies clade reintroduction
Shannon N. Bennett,Edward C. Holmes,Maritza Chirivella,Dania M. Rodriguez,Manuela Beltran,Vance Vorndam,Duane J. Gubler,W. Owen McMillan +7 more
TL;DR: Molecular evolution in DENV-2 from Puerto Rico (PR) and surrounding countries was examined over a 20 year period of fluctuating disease incidence, and strong evidence was found for positive selection acting on a number of amino acid sites in the envelope gene, which have also been important in defining phylogenetic structure.
Journal ArticleDOI
Insights into the molecular evolution of Dengue virus type 4 in Puerto Rico over two decades of emergence
Estelle Martin,Maritza Chirivella,Juliene K.G. Co,Gilberto A. Santiago,Duane J. Gubler,Jorge L. Muñoz-Jordán,Shannon N. Bennett,Shannon N. Bennett +7 more
TL;DR: This study confirms that DENVs evolve through rapid lineage turnover driven in part by natural selection and genetic drift, and shows that DENV-4 strains from these periods were genetically distinct based on unique changes in the envelope and non-structural genes.