Marjukka Myllärniemi

TL;DR: It is demonstrated that, after endothelial denudation of rat carotid artery, the mRNA of the classical estrogen receptor (ERα) is constitutively expressed at a low level whereas the expression of the novel ERβ mRNA increases >40-fold, suggesting that preferential targeting to ERβ will provide vasculoprotective estrogen analogs devoid of effects to the reproductive system.

TL;DR: It is observed that the BMP antagonist, gremlin, is highly up-regulated in idiopathic pulmonary fibrosis (IPF), and analyses of cultured human bronchial epithelial cells indicated that asbestos-induced gremlin expression could be prevented by inhibitor of the TGF-beta receptor and also by inhibitors of the mitogen-activated protein kinase kinase/extracellular signal-regulatedprotein kinase pathways.

TL;DR: The oxidative effects of cigarette smoking have been found to activate TGF-beta in chronic obstructive pulmonary disease (COPD), a disease consisting of emphysema, airway fibrosis, and focal lung fibrosis.

TL;DR: The overexpression of this developmental gene in IPF may be a key event in the persistence of myofibroblasts in the lung interstitium and provides a potential target for therapeutic intervention.

TL;DR: Extracellular SOD regulation in response to pulmonary fibrosis in animals and humans is discussed and possible mechanisms by which EC-SOD may protect against fibrosis are reviewed.