Mark B. Knudson

TL;DR: A system for designing a therapy or for treating a gastrointestinal disorder or a condition associated with excess weight in a subject comprising at least one electrode configured to be implanted within a body of the patient and placed at a vagus nerve is described in this article.

TL;DR: In this paper, an electrical signal is applied to the electrode to modulate vagal activity, and the application of the electrical signal and discontinuing of the signal are repeated with durations of the discontinuing and application selected to treat the disorder.

TL;DR: In this paper, a method for treating at least one of a plurality of disorders characterized at least in part by vagal activity is described, where an electrode is placed at a body organ innervated by the vagus.

TL;DR: Among patients with morbid obesity, the use of vagal nerve block therapy compared with a sham control device did not meet either of the prespecified coprimary efficacy objectives, although weight loss in the vagal block group was statistically greater than in the sham device group.

TL;DR: Intermittent, intra-abdominal vagal blocking is associated with significant EWL and a desirable safety profile and an open-label, 3-center study was conducted in obese subjects.