M
Mark E. C. Dockrell
Researcher at St Helier Hospital
Publications - 7
Citations - 259
Mark E. C. Dockrell is an academic researcher from St Helier Hospital. The author has contributed to research in topics: Gene knockdown & Serum albumin. The author has an hindex of 7, co-authored 7 publications receiving 243 citations.
Papers
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Journal ArticleDOI
The differential role of Smad2 and Smad3 in the regulation of pro-fibrotic TGFβ1 responses in human proximal-tubule epithelial cells
TL;DR: Different roles for Smad2 and Smad3 are demonstrated in TGFbeta1-induced CTGF expression and markers of EMT in human PTECs, which can be of therapeutic value in designing targeted anti-fibrotic therapies for tubulo-interstitial fibrosis.
Book ChapterDOI
Primary culture of human renal proximal tubule epithelial cells and interstitial fibroblasts.
TL;DR: This chapter outlines methods by which proximal tubular epithelial cells and renal interstitial fibroblasts can be isolated and characterized from human renal nephrectomy tissue.
Journal ArticleDOI
Metformin attenuates the effect of Staphylococcus aureus on airway tight junctions by increasing PKCζ‐mediated phosphorylation of occludin
Kameljit K. Kalsi,James P. Garnett,Wishwanath R. A. Patkee,Alexina Weekes,Mark E. C. Dockrell,Emma H. Baker,Deborah L. Baines +6 more
TL;DR: It is demonstrated that metformin improves TJ barrier function by promoting the abundance and assembly of full length occludin at the TJ and that this process involves phosphorylation of the protein via an AMPK‐PKCζ pathway.
Journal Article
Albumin induces interleukin-6 release from primary human proximal tubule epithelial cells.
TL;DR: It is demonstrated that albumin induces IL-6 release by primary human PTECs, and support a role for endocytosis, p38 MAPK, ERK1,2 and in this process.
Journal ArticleDOI
The Regulation of TGFβ1 Induced Fibronectin EDA Exon Alternative Splicing in Human Renal Proximal Tubule Epithelial Cells
Mysore K Phanish,Felicia Heidebrecht,Mohammad E. Nabi,Nileshkumar Shah,Ioana Niculescu-Duvaz,Mark E. C. Dockrell +5 more
TL;DR: The first evidence for the regulation of Fn pre‐mRNA splicing by PI3 kinase‐AKT signalling and SRp40 in human PTECs is presented andargeting the splicing of FnPre‐m RNA to skip the EDA exon is an attractive option to combat fibrosis.