M
Mark Hartmann
Researcher at University of Mainz
Publications - 3
Citations - 1395
Mark Hartmann is an academic researcher from University of Mainz. The author has contributed to research in topics: Superoxide & Nitric oxide. The author has an hindex of 3, co-authored 3 publications receiving 1352 citations.
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Journal ArticleDOI
Mechanisms Underlying Endothelial Dysfunction in Diabetes Mellitus
Ulrich Hink,Huige Li,Hanke Mollnau,Mathias Oelze,Edi Matheis,Mark Hartmann,Mikhail Skatchkov,Friedrich Thaiss,Rolf A.K. Stahl,Ascan Warnholtz,Thomas Meinertz,Kathy K. Griendling,David G. Harrison,Ulrich Förstermann,Thomas Münzel +14 more
TL;DR: In vivo and in vitro studies have indicated a crucial role of the diacylglycerol-protein kinase C (PKC) pathway in mediatingHyperglycemia is the major causal factor in the development of endothelial dysfunction in patients with diabetes mellitus.
Journal ArticleDOI
Effects of Long-Term Nitroglycerin Treatment on Endothelial Nitric Oxide Synthase (NOS III) Gene Expression, NOS III–Mediated Superoxide Production, and Vascular NO Bioavailability
Thomas Münzel,Huige Li,Hanke Mollnau,Ulrich Hink,Edi Matheis,Mark Hartmann,Mathias Oelze,Mikhail Skatchkov,Ascan Warnholtz,Linda Duncker,Thomas Meinertz,Ulrich Förstermann +11 more
TL;DR: NTG treatment increases the expression of a dysfunctional NOS III gene, leading to increased formation of O(2)(.-) and decreased vascular NO bioavailability, and an important role for PKC isoforms in mediating vascular dysfunction caused by long-term NTG treatment is suggested.
Journal ArticleDOI
Effects of a nitrate-free interval on tolerance, vasoconstrictor sensitivity and vascular superoxide production ☆
Thomas Münzel,Hanke Mollnau,Mark Hartmann,Carolin Geiger,Mathias Oelze,Ascan Warnholtz,Abdullah Hay Yehia,Ulrich Förstermann,Thomas Meinertz +8 more
TL;DR: Enhanced vasoconstrictor sensitivity may explain, at least in part, the rebound phenomena observed in patients during a 12-h NTG patch-off period.