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Mark J. Nijland
Researcher at University of Texas Health Science Center at San Antonio
Publications - 111
Citations - 4423
Mark J. Nijland is an academic researcher from University of Texas Health Science Center at San Antonio. The author has contributed to research in topics: Fetus & Offspring. The author has an hindex of 37, co-authored 109 publications receiving 4123 citations. Previous affiliations of Mark J. Nijland include University of Texas at San Antonio & Cornell University.
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Maternal undernutrition during early to mid-gestation in the ewe results in altered growth, adiposity, and glucose tolerance in male offspring.
Stephen P. Ford,Bret W. Hess,M. M. Schwope,Mark J. Nijland,Mark J. Nijland,Jeffrey S. Gilbert,Kimberly A. Vonnahme,W. J. Means,H. Han,Peter W. Nathanielsz,Peter W. Nathanielsz +10 more
TL;DR: It is demonstrated that a bout of maternal undernutrition during early to midgestation in sheep increased BW and fat deposition during adolescence and dysregulated glucose uptake in the absence of any change in birth weight.
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Maternal Undernutrition from Early- to Mid-Gestation Leads to Growth Retardation, Cardiac Ventricular Hypertrophy, and Increased Liver Weight in the Fetal Sheep
Kimberly A. Vonnahme,Bret W. Hess,Thomas R. Hansen,Richard J. McCormick,Daniel C. Rule,Gary E. Moss,William J. Murdoch,Mark J. Nijland,Donal C. Skinner,Peter W. Nathanielsz,Stephen P. Ford +10 more
TL;DR: Altered alterations in fetal/placental development may be beneficial to early fetal survival in the face of a nutrient restriction, but their effects later in gestation as well as in postnatal life need further investigation.
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Maternal nutrient restriction in sheep: hypertension and decreased nephron number in offspring at 9 months of age
TL;DR: This article showed that global maternal nutrient restriction during early to mid-gestation impairs renal nephrogenesis, increases MAP, and alters expression of angiotensin converting enzyme (ACE) without an associated change in birth weight.
Journal ArticleDOI
Maternal obesity and increased nutrient intake before and during gestation in the ewe results in altered growth, adiposity, and glucose tolerance in adult offspring.
Nathan M. Long,Lindsey A. George,Adam B. Uthlaut,Derek T. Smith,Mark J. Nijland,Peter W. Nathanielsz,Stephen P. Ford +6 more
TL;DR: Maternal obesity induced before and during gestation leads to alterations in appetite, glucose and insulin regulation, and adiposity of mature offspring.
Journal ArticleDOI
Maternal obesity accelerates fetal pancreatic β-cell but not α-cell development in sheep: prenatal consequences
Stephen P. Ford,Liren Zhang,Mei-Jun Zhu,Myrna M. Miller,Derek T. Smith,Bret W. Hess,Gary E. Moss,Peter W. Nathanielsz,Mark J. Nijland +8 more
TL;DR: It is concluded that increased systemic insulin in fetuses from OB ewes results from increased glucose exposure and/or cortisol-induced accelerated fetal beta-cell maturation and may contribute to premature beta- cell function loss and predisposition to obesity and metabolic disease in offspring.