M
Mark K. Eskandari
Researcher at University of Michigan
Publications - 8
Citations - 1109
Mark K. Eskandari is an academic researcher from University of Michigan. The author has contributed to research in topics: Tumor necrosis factor alpha & In vivo. The author has an hindex of 8, co-authored 8 publications receiving 1105 citations.
Papers
More filters
Journal Article
Anti-tumor necrosis factor antibody therapy fails to prevent lethality after cecal ligation and puncture or endotoxemia.
Mark K. Eskandari,G. L. Bolgos,Christopher J. Miller,D. T. Nguyen,Laura E. DeForge,Daniel G. Remick +5 more
TL;DR: Blockade of TNF biologic activity will not prevent lethality in two separate models of septic shock, and an anti-TNF antibody that has been shown previously to inhibit in vivo TNF activity is treated.
Journal ArticleDOI
Monokine-induced neutrophil chemotactic factor gene expression in human fibroblasts.
Robert M. Strieter,Sem H. Phan,H. J. Showell,Daniel G. Remick,Joseph P. Lynch,M. Genord,C. L. Raiford,Mark K. Eskandari,Rory M. Marks,Steven L. Kunkel +9 more
TL;DR: Evidence is provided that monokine-treated fibroblasts can synthesize a potent chemotactic agent with molecular and physicochemical characteristics similar to monocyte-derived NCF and that this factor may contribute to neutrophil-mediated disease processes.
Journal Article
Role of tumor necrosis factor-α in lipopolysaccharide-induced pathologic alterations
Daniel G. Remick,Robert M. Strieter,Mark K. Eskandari,D. T. Nguyen,M. Genord,C. L. Raiford,Steven L. Kunkel +6 more
TL;DR: It is demonstrated that TNF plays an important role in the early pathophysiologic alterations that occur after systemic exposure to LPS.
Journal ArticleDOI
Wehi 164 subclone 13 assay for TNF : sensitivity, specificity, and reliability
TL;DR: The WEHI assay has successfully detected cytolytic activity from lipopolysaccharide stimulated specimens from a number of different species, and data show the utility of this highly sensitive and specific assay.
Journal Article
In vivo dynamics of murine tumor necrosis factor-alpha gene expression. Kinetics of dexamethasone-induced suppression
Daniel G. Remick,Robert M. Strieter,J P Lynch rd,D. T. Nguyen,Mark K. Eskandari,Steven L. Kunkel +5 more
TL;DR: In vivo effects of lipopolysaccharide on the kinetics of local and systemic TNF production, the time dependent expression of T NF mRNA, and the suppression of both TNF mRNA and bioactive protein are described using a defined treatment protocol of Dex.