M
Mark K. Shigenaga
Researcher at Children's Hospital Oakland Research Institute
Publications - 62
Citations - 19303
Mark K. Shigenaga is an academic researcher from Children's Hospital Oakland Research Institute. The author has contributed to research in topics: DNA damage & Oxidative stress. The author has an hindex of 37, co-authored 62 publications receiving 18631 citations. Previous affiliations of Mark K. Shigenaga include Boston Children's Hospital & University of California, Berkeley.
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Oxidants, antioxidants, and the degenerative diseases of aging
TL;DR: It is argued that this damage to DNA, protein, and lipid is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts.
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Oxidative damage and mitochondrial decay in aging
TL;DR: Evidence supports the suggestion that age-associated accumulation of mitochondrial deficits due to oxidative damage is likely to be a major contributor to cellular, tissue, and organismal aging.
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Oxidative damage to DNA during aging: 8-hydroxy-2'-deoxyguanosine in rat organ DNA and urine.
TL;DR: The results suggest that the age-dependent accumulation of oh8dG residues observed in DNA from liver, kidney, and intestine is principally due to the slow loss of DNA nuclease activity; however, an increase in the rate of oxidative DNA damage cannot be ruled out.
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Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.
Cesar G. Fraga,Paul A. Motchnik,Mark K. Shigenaga,Harold J. Helbock,Robert A. Jacob,Bruce N. Ames +5 more
TL;DR: Dietary AA protects human sperm from endogenous oxidative DNA damage that could affect sperm quality and increase risk of genetic defects, particularly in populations with low AA such as smokers.
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gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention.
TL;DR: It is suggested that gamma-tocopherol may contribute significantly to human health in ways not recognized previously, and this possibility should be further evaluated, especially considering that high doses of alpha-tocaperol deplete plasma and tissue gamma-Tocopherol, in contrast with supplementation withGamma-CEHC, which increases both.