P
Paul A. Motchnik
Researcher at University of California, Berkeley
Publications - 15
Citations - 2772
Paul A. Motchnik is an academic researcher from University of California, Berkeley. The author has contributed to research in topics: Lipid peroxidation & Ascorbic acid. The author has an hindex of 13, co-authored 15 publications receiving 2696 citations. Previous affiliations of Paul A. Motchnik include University of California, Davis.
Papers
More filters
Journal ArticleDOI
Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.
Cesar G. Fraga,Paul A. Motchnik,Mark K. Shigenaga,Harold J. Helbock,Robert A. Jacob,Bruce N. Ames +5 more
TL;DR: Dietary AA protects human sperm from endogenous oxidative DNA damage that could affect sperm quality and increase risk of genetic defects, particularly in populations with low AA such as smokers.
Journal ArticleDOI
Smoking and low antioxidant levels increase oxidative damage to sperm DNA.
TL;DR: The possibility that paternal smoking causes mutations in sperm that lead to cancer, birth defects, and genetic diseases in offspring is discussed.
Journal Article
Antioxidant protection against hypochlorous acid in human plasma.
TL;DR: It seems that -SH groups are a major target of attack by HOCI/OCI- in vivo, and plasma albumin may be an important protective antioxidant.
Journal ArticleDOI
Modification of plasma proteins by cigarette smoke as measured by protein carbonyl formation
Abraham Z. Reznick,Carroll E. Cross,Miao Lin Hu,Yuichiro J. Suzuki,S. Khwaja,A. Safadi,Paul A. Motchnik,Lester Packer,Barry Halliwell +8 more
TL;DR: Direct addition to plasma of mixtures of some or all of the aldehydes reported to be present in CS caused protein carbonyl formation and inactivation of CK, but neither occurred to the extent produced by CS exposure.
Book ChapterDOI
Measurement of antioxidants in human blood plasma.
TL;DR: The HPLC-EC technique combines selectivity with high sensitivity for measuring both water- and lipid-soluble antioxidants and allows one to measure a panel of antioxidants in a small volume of plasma.