T
Tory M. Hagen
Researcher at Oregon State University
Publications - 79
Citations - 16105
Tory M. Hagen is an academic researcher from Oregon State University. The author has contributed to research in topics: Lipoic acid & Oxidative stress. The author has an hindex of 39, co-authored 77 publications receiving 15318 citations. Previous affiliations of Tory M. Hagen include IMDEA & Linus Pauling Institute.
Papers
More filters
Journal ArticleDOI
Oxidants, antioxidants, and the degenerative diseases of aging
TL;DR: It is argued that this damage to DNA, protein, and lipid is a major contributor to aging and to degenerative diseases of aging such as cancer, cardiovascular disease, immune-system decline, brain dysfunction, and cataracts.
Journal ArticleDOI
Oxidative damage and mitochondrial decay in aging
TL;DR: Evidence supports the suggestion that age-associated accumulation of mitochondrial deficits due to oxidative damage is likely to be a major contributor to cellular, tissue, and organismal aging.
Journal ArticleDOI
Alpha-lipoic acid as a dietary supplement: Molecular mechanisms and therapeutic potential
TL;DR: Though LA has long been touted as an antioxidant, it has also been shown to improve glucose and ascorbate handling, increase eNOS activity, activate Phase II detoxification via the transcription factor Nrf2, and lower expression of MMP-9 and VCAM-1 through repression of NF-kappa B.
Journal ArticleDOI
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid
Jung H. Suh,Swapna V. Shenvi,Brian Dixon,Honglei Liu,Anil K. Jaiswal,Rui-Ming Liu,Tory M. Hagen +6 more
TL;DR: The age-related loss in GSH synthesis may be caused by dysregulation of ARE-mediated gene expression, but chemoprotective agents, like LA, can attenuate this loss.
Journal ArticleDOI
Selective fluorescent imaging of superoxide in vivo using ethidium-based probes
Kristine M. Robinson,Michael S. Janes,Mariana Pehar,Jeffrey S. Monette,Meredith F. Ross,Tory M. Hagen,Michael P. Murphy,Joseph S. Beckman +7 more
TL;DR: It is found that the superoxide product of both HE and Mito-HE could be selectively excited at 396 nm with minimal interference from other nonspecific oxidation products, indicating the more selective detection of superoxide in vivo.