M
Mark Malia
Publications - 1
Citations - 554
Mark Malia is an academic researcher. The author has contributed to research in topics: Native state & Peptide. The author has an hindex of 1, co-authored 1 publications receiving 543 citations.
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A comparison of strategies to stabilize immunoglobulin Fv-fragments.
TL;DR: Three different strategies on the Fv-fragment of the well-characterized phosphocholine binding antibody McPC603 expressed and secreted in Escherichia coli are tested: chemical cross-linking of the variable domains, introduction of an intermolecular disulfide bond, and construction of a peptide linker to produce a "single-chain" Fv