Mark S. Guyer

TL;DR: The articles that follow from seven of the Centers for Data Excellence that have been funded by the National Institutes of Health (NIH) Big Data to Knowledge (BD2K) initiative provide an overall context for the program.

TL;DR: The majority of this supplement is devoted to a series of worked examples, providing an overview of the types of data available, details on how these data can be browsed, and stepby-step instructions for using many of the most commonly-used tools for sequence-based discovery.

TL;DR: It is sometimes hard to remember that the first DNA sequence of the entire genome of a free-living organism, Hemophilus influenzae, was reported 17 other prokaryotes, and it is important that the Human Genome Project (HGP) devise a way of measuring and reporting the quality of sequence data deposited in the public databases.

TL;DR: The rapid progress that has already been made; the impact that the resources already developed have had on the ability of investigators to identify and isolate human genes, particularly those associated with disease; and the promise that the project offers for profoundly altering the approach to medical care.

TL;DR: The program's influence is likely to grow as ELSi research, genomics research, and policy development activities become increasingly integrated, and the benefits of increased integration while preserving the autonomy, objectivity, and intellectual independence of ELSI investigators presents ongoing challenges and new opportunities.